Cannabidiol/hydroxypropyl-beta-cyclodextrin inclusion complex: structure analysis, release behavior, permeability, and bioactivity under in vitro digestion
文献类型：期刊论文
| 作者 | Li, Hang1,2; Zhao, Qingsheng1,2 ; Wang, Liwei1; Wang, Peidong1,2; Zhao, Bing1
|
| 刊名 | NEW JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2022-03-07 |
| 卷号 | 46期号:10页码:4700-4709 |
| ISSN号 | 1144-0546 |
| DOI | 10.1039/d1nj05998j |
| 英文摘要 | Cannabidiol (CBD), a natural phenolic compound, has many promising biological activities, but its use in food or other fields is restricted owing to inferior water solubility. So hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was selected to form the inclusion complex (IC) of CBD to improve its solubility. The results showed CBD/HP-beta-CD IC was formed at a 1 : 1 molar ratio. The complexation was spontaneous, endothermic, and entropy-driven. The loading efficiency (LE) and complexation efficiency (CE) were 16.2% and 95.1%, respectively. NMR revealed CBD/HP-beta-CD IC was formed through incorporating the benzene ring of CBD into the HP-beta-CD cavity. The water solubility was greatly enhanced to 9.4 mu g mL(-1). About 80% of CBD molecules in the IC were released in simulated intestinal juice. The permeability, radical scavenging ability, and in vitro cytotoxicity of CBD were enhanced significantly after complexation. And the radical scavenging ability of digested IC was less potent compared with undigested IC but still stronger than that of CBD. |
| WOS关键词 | ANTIOXIDANT ACTIVITY ; DRUG-DELIVERY ; CANNABIDIOL ; FORMULATION |
| 资助项目 | Yunnan Hempmon Pharmaceutical Co.,Ltd. |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000760907700001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | Yunnan Hempmon Pharmaceutical Co.,Ltd. |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/52224]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Zhao, Qingsheng; Zhao, Bing |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Hang,Zhao, Qingsheng,Wang, Liwei,et al. Cannabidiol/hydroxypropyl-beta-cyclodextrin inclusion complex: structure analysis, release behavior, permeability, and bioactivity under in vitro digestion[J]. NEW JOURNAL OF CHEMISTRY,2022,46(10):4700-4709. |
| APA | Li, Hang,Zhao, Qingsheng,Wang, Liwei,Wang, Peidong,&Zhao, Bing.(2022).Cannabidiol/hydroxypropyl-beta-cyclodextrin inclusion complex: structure analysis, release behavior, permeability, and bioactivity under in vitro digestion.NEW JOURNAL OF CHEMISTRY,46(10),4700-4709. |
| MLA | Li, Hang,et al."Cannabidiol/hydroxypropyl-beta-cyclodextrin inclusion complex: structure analysis, release behavior, permeability, and bioactivity under in vitro digestion".NEW JOURNAL OF CHEMISTRY 46.10(2022):4700-4709. |
入库方式： OAI收割
来源：过程工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。