Amino-Acid-Encoded Supramolecular Photothermal Nanomedicine for Enhanced Cancer Therapy
文献类型：期刊论文
| 作者 | Chang, Rui1,2; Zou, Qianli1,3; Zhao, Luyang1; Liu, Yamei1; Xing, Ruirui1,2; Yan, Xuehai1,2,4 |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2022-03-13 |
| 页码 | 9 |
| 关键词 | amino acid encoding cancer photothermal therapy noncovalent interactions self-assembly supramolecular nanomedicine |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.202200139 |
| 英文摘要 | Photothermal nanomedicine based on self-assembly of biological components, with excellent biosafety and customized performance, is vital significance for precision cancer therapy. However, the programmable design of photothermal nanomedicine remains extremely challenging due to the vulnerability and variability of noncovalent interactions governing supramolecular self-assembly. Herein, it is reported that amino acid encoding is a facile and potent means to design and construct supramolecular photothermal nanodrugs with controlled therapeutic activities. It is found that the amount and type of amino acid dominates the assembled nanostructures, structural stability, energy-conversion pathway, and therapeutic mechanism of the resulting nanodrugs. Two optimized nanodrugs are endowed with robust structural integrity against disassembly along with high photothermal conversion efficiency, efficient cellular internalization, and enhanced tumor accumulation, which result in more efficient tumor ablation. This work demonstrates that design based on amino acid encoding offers an unprecedented opportunity for the construction of remarkable photoactive nanomedicines toward cancer diagnostics and therapeutics. |
| WOS关键词 | PIGMENTS |
| 资助项目 | National Science Fund for Distinguished Young Scholars of China[22025207] ; Innovation Research Community Science Fund of China[21821005] ; National Natural Science Foundation of China[22072154] ; National Natural Science Foundation of China[21977095] ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)[QYZDB-SSWJSC034] ; National Natural Science Foundation of Hebei Province[B2020103025] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000769611100001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | National Science Fund for Distinguished Young Scholars of China ; Innovation Research Community Science Fund of China ; National Natural Science Foundation of China ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS) ; National Natural Science Foundation of Hebei Province |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/52232]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Xing, Ruirui; Yan, Xuehai |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 3.Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chang, Rui,Zou, Qianli,Zhao, Luyang,et al. Amino-Acid-Encoded Supramolecular Photothermal Nanomedicine for Enhanced Cancer Therapy[J]. ADVANCED MATERIALS,2022:9. |
| APA | Chang, Rui,Zou, Qianli,Zhao, Luyang,Liu, Yamei,Xing, Ruirui,&Yan, Xuehai.(2022).Amino-Acid-Encoded Supramolecular Photothermal Nanomedicine for Enhanced Cancer Therapy.ADVANCED MATERIALS,9. |
| MLA | Chang, Rui,et al."Amino-Acid-Encoded Supramolecular Photothermal Nanomedicine for Enhanced Cancer Therapy".ADVANCED MATERIALS (2022):9. |
入库方式： OAI收割
来源：过程工程研究所
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