High molecular weight chitosan oligosaccharide exhibited antifungal activity by misleading cell wall organization via targeting PHR transglucosidases
文献类型：期刊论文
| 作者 | Li, Ruilian1,2; Zhu, Limeng1,2; Liu, Dongdong2; Wang, Wenjing2,3; Zhang, Chen1,2; Jiao, Siming2; Wei, Jinhua1,2; Ren, Lishi2; Zhang, Yuchen2; Gou, Xun3 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2022-06-01 |
| 卷号 | 285页码:14 |
| ISSN号 | 0144-8617 |
| 关键词 | Candida albicans Cell wall Biofilm Chitosan oligosaccharide PHR transglucosidases |
| DOI | 10.1016/j.carbpol.2022.119253 |
| 英文摘要 | The fungal cell wall is an ideal target for the design of antifungal drugs. In this study we used an analog of cell wall polymer, a highly deacetylated high molecular-weight chitosan oligosaccharide (HCOS), to test its effect against pathogenic Candida strains. Results showed that HCOS was successfully incorporated into the dynamic cell wall organization process and exhibited an apparent antifungal activity against both plankton and mature fungal biofilm, by impairing the cell wall integrity. Unexpectedly, mechanistic studies suggested that HCOS exerts its activity by interfering with family members of PHR beta-(1,3)-glucanosyl transferases and affecting the connection and assembly of cell wall polysaccharides. Furthermore, HCOS showed great synergistic activity with different fungicides against Candida cells, especially those in biofilm. These findings indicated HCOS has a great potential as an antifungal drug or drug synergist and proposed a novel antifungal strategy with structure-specific oligosaccharides mimicking cell wall polysaccharide fragments. |
| WOS关键词 | CANDIDA-ALBICANS ; IN-VITRO ; SACCHAROMYCES-CEREVISIAE ; PLASMA-MEMBRANE ; CHITIN ; VIRULENCE ; BIOSYNTHESIS ; INTEGRITY ; PROTEINS ; DEFENSE |
| 资助项目 | National Key Research and Development Program of China[2018YFC0311300] ; National Natural Science Fund, China[31670809] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000761017700002 |
| 资助机构 | National Key Research and Development Program of China ; National Natural Science Fund, China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/52279]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Du, Yuguang; Wang, Zhuo A. |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Sichuan Normal Univ, Coll Life Sci, Chengdu 610101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ruilian,Zhu, Limeng,Liu, Dongdong,et al. High molecular weight chitosan oligosaccharide exhibited antifungal activity by misleading cell wall organization via targeting PHR transglucosidases[J]. CARBOHYDRATE POLYMERS,2022,285:14. |
| APA | Li, Ruilian.,Zhu, Limeng.,Liu, Dongdong.,Wang, Wenjing.,Zhang, Chen.,...&Wang, Zhuo A..(2022).High molecular weight chitosan oligosaccharide exhibited antifungal activity by misleading cell wall organization via targeting PHR transglucosidases.CARBOHYDRATE POLYMERS,285,14. |
| MLA | Li, Ruilian,et al."High molecular weight chitosan oligosaccharide exhibited antifungal activity by misleading cell wall organization via targeting PHR transglucosidases".CARBOHYDRATE POLYMERS 285(2022):14. |
入库方式： OAI收割
来源：过程工程研究所
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