Engineering mannosylated pickering emulsions for the targeted delivery of multicomponent vaccines
文献类型：期刊论文
| 作者 | Du, Yiqun1,2; Song, Tiantian1,3; Wu, Jie1,3; Gao, Xiao-Dong4; Ma, Guanghui1,3; Liu, Yuchen2; Xia, Yufei1,3 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2022 |
| 卷号 | 280页码:11 |
| 关键词 | Cancer vaccine Pickering emulsion Targeted vaccine delivery system Mannose CpG |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2021.121313 |
| 英文摘要 | While research on cancer vaccines has made great strides in the field of immunotherapy, the targeted delivery of multiple effective components (rational-tailored antigens and adjuvants) remains a challenge. Here, we utilized the unique hierarchical structures of Pickering emulsions (particles, oil core, and water-oil interface) to develop mannosylated (M) Pickering emulsions (PE) that target antigen presenting cells and synergistically deliver antigenic peptides and the TLR9 agonist CpG (C) as an enhanced cancer vaccine (MPE-C). We chemically linked mannose residues to PLGA/PLAG-PEG nanoparticles and produced a dense array of mannose on the nano patterned surface of Pickering emulsions, allowing for increased cellular targeting. Together with the inherent deformability of the oily core, MPE-C increased the droplet-cellular contact area and provoked the cellular recognition of mannose and CpG for enhanced immune activation. We found that MPE-C attracted a large number of APCs to the local site of administration, evidently increasing cellular uptake and activation. Additionally, we observed increased antigen-specific cellular immune responses, with potent anti-tumor effects against both E.G7-OVA and B16-MUCI tumors. Furthermore, MPE-C combined with PD-1 antibodies produced a significant tumor regression, resulting in synergistic increases in anti-tumor effects. Thus, through the strategic loading of mannose, antigens, and CpG, Pickering emulsions could serve as a targeted delivery platform for enhanced multicomponent cancer vaccines. |
| WOS关键词 | LYMPH-NODE ; CANCER ; NANOVACCINE ; ADJUVANTS ; INNATE |
| 资助项目 | Foundation for CAS Project for Young Scientists in Basic Research[YSBR-010] ; Pilot Project of Chinese Academy of Sciences[XDB29040303] ; China Postdoctoral Science Foundation[2020TQ0205] ; China Postdoctoral Science Foundation[2020M682906] ; "From 0 to 1" Original Innovation Project of Basic Frontier Scientific Research Program of Chinese Academy of Sciences[ZDBS-LY-SLH040] ; Project of National Natural Science Foundation of China[21908229] ; Project of National Natural Science Foundation of China[81773257] ; Project of National Natural Science Foundation of China[81972867] ; Innovative Research Groups of the National Natural Science Foundation of China[21821005] ; Beijing Nova Program of Beijing Municipal Science & Technology Commission[Z201100006820139] ; Project of National Key R&D Program of China[2021YFA0911600] ; Project of Natural Science Foundation of Guangdong Province[2018B030306023] ; Shenzhen Municipal Science and Technology Innovation Council[RCYX20200714114701035] ; Shenzhen Municipal Science and Technology Innovation Council[JCYJ20180507184642475] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000783915900002 |
| 出版者 | ELSEVIER SCI LTD |
| 资助机构 | Foundation for CAS Project for Young Scientists in Basic Research ; Pilot Project of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; "From 0 to 1" Original Innovation Project of Basic Frontier Scientific Research Program of Chinese Academy of Sciences ; Project of National Natural Science Foundation of China ; Innovative Research Groups of the National Natural Science Foundation of China ; Beijing Nova Program of Beijing Municipal Science & Technology Commission ; Project of National Key R&D Program of China ; Project of Natural Science Foundation of Guangdong Province ; Shenzhen Municipal Science and Technology Innovation Council |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/52713]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Liu, Yuchen; Xia, Yufei |
| 作者单位 | 1.Inst Proc Engn, Chinese Acad Sci, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.First Affiliated Hosp Shenzhen Univ, Shenzhen Peoples Hosp 2, Shenzhen Inst Translat Med, Hlth Sci Ctr, Shenzhen 518035, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100190, Peoples R China 4.Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi 214122, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Yiqun,Song, Tiantian,Wu, Jie,et al. Engineering mannosylated pickering emulsions for the targeted delivery of multicomponent vaccines[J]. BIOMATERIALS,2022,280:11. |
| APA | Du, Yiqun.,Song, Tiantian.,Wu, Jie.,Gao, Xiao-Dong.,Ma, Guanghui.,...&Xia, Yufei.(2022).Engineering mannosylated pickering emulsions for the targeted delivery of multicomponent vaccines.BIOMATERIALS,280,11. |
| MLA | Du, Yiqun,et al."Engineering mannosylated pickering emulsions for the targeted delivery of multicomponent vaccines".BIOMATERIALS 280(2022):11. |
入库方式： OAI收割
来源：过程工程研究所
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