Novel process for selective separation of trace artemisitene from artemisinin by ammonium functional ionic liquids
文献类型：期刊论文
| 作者 | Cao, Yingying1,2; Tan, Xin1,2; Zhan, Guoxiong1,2; Li, Qiongguang1,2; Wang, Hui1,2; Li, Zengxi2 |
| 刊名 | AICHE JOURNAL
 |
| 出版日期 | 2022-04-23 |
| 页码 | 13 |
| 关键词 | artemisinin/artemisitene ionic liquids multistage extraction selective separation pi-pi complexation |
| ISSN号 | 0001-1541 |
| DOI | 10.1002/aic.17711 |
| 英文摘要 | One of the challenges to obtain high-quality natural active substances is the selective separation of the target compound from its analogues. In this study, ionic liquids (ILs), with design flexibility, were proposed to separate artemisitene and artemisinin, typical examples of natural analogues. Based on COSMO-RS calculation, several ILs were selected to separate artemisitene/artemisinin by experiment. It was demonstrated that the aqueous solution of N-allyl-N,N,N-trimethylammonium chloride ([AA][Cl]) exhibited excellent capability for selective separation of the two compounds. Under the optimal conditions (40 degrees C, 1 h), the separation selectivity of artemisitene/artemisinin could reach 12.23 when the initial impurity content was only 0.8 wt%. Spectroscopic analysis and molecular dynamics indicated that pi-pi complexation between artemisitene and [AA][Cl] plays a major role in this separation process. Moreover, the process of multistage cross-flow extraction was compared with counter-flow extraction, and the latter one exhibited advantages in energy consumption and product yield. |
| WOS关键词 | PHENOLIC-COMPOUNDS ; EXTRACTION ; HOMOLOGS ; TERPENOIDS ; TOCOPHEROL ; MIXTURES |
| 资助项目 | National Natural Science Foundation of China[22078324] ; Alliance of International Science Organizations[ANSO-CR-KP-202111] ; CAS Pioneer Hundred Talents Program ; Innovation Academy for Green Manufacture, Chinese Academy of Sciences[IAGM-2019-A12] |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:000785931600001 |
| 出版者 | WILEY |
| 资助机构 | National Natural Science Foundation of China ; Alliance of International Science Organizations ; CAS Pioneer Hundred Talents Program ; Innovation Academy for Green Manufacture, Chinese Academy of Sciences |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/52852]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Wang, Hui; Li, Zengxi |
| 作者单位 | 1.Chinese Acad Sci, Innovat Acad Green Manufacture, Inst Proc Engn,State Key Lab Multiphase Complex S, Beijing Key Lab Ion Liquids Clean Proc,CAS Key La, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Coll Chem Engn, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Yingying,Tan, Xin,Zhan, Guoxiong,et al. Novel process for selective separation of trace artemisitene from artemisinin by ammonium functional ionic liquids[J]. AICHE JOURNAL,2022:13. |
| APA | Cao, Yingying,Tan, Xin,Zhan, Guoxiong,Li, Qiongguang,Wang, Hui,&Li, Zengxi.(2022).Novel process for selective separation of trace artemisitene from artemisinin by ammonium functional ionic liquids.AICHE JOURNAL,13. |
| MLA | Cao, Yingying,et al."Novel process for selective separation of trace artemisitene from artemisinin by ammonium functional ionic liquids".AICHE JOURNAL (2022):13. |
入库方式： OAI收割
来源：过程工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。