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Advances in oral peptide drug nanoparticles for diabetes mellitus treatment

文献类型：期刊论文

作者Li, Yan1; Zhang, Wen1; Zhao, Ruichen2,3; Zhang, Xin2
刊名BIOACTIVE MATERIALS
出版日期2022-09-01
卷号15页码:392-408
关键词Oral nanoparticles Peptide drugs Gastrointestinal tract Diabetes mellitus Oral bioavailability
DOI10.1016/j.bioactmat.2022.02.025
英文摘要Peptide drugs play an important role in diabetes mellitus treatment. Oral administration of peptide drugs is a promising strategy for diabetes mellitus because of its convenience and high patient compliance compared to parenteral administration routes. However, there are a series of formidable unfavorable conditions present in the gastrointestinal (GI) tract after oral administration, which result in the low oral bioavailability of these peptide drugs. To overcome these challenges, various nanoparticles (NPs) have been developed to improve the oral absorption of peptide drugs due to their unique in vivo properties and high design flexibility. This review discusses the unfavorable conditions present in the GI tract and provides the corresponding strategies to overcome these challenges. The review provides a comprehensive overview on the NPs that have been constructed for oral peptide drug delivery in diabetes mellitus treatment. Finally, we will discuss the rational application and give some suggestions that can be utilized for the development of oral peptide drug NPs. Our aim is to provide a systemic and comprehensive review of oral peptide drug NPs that can overcome the challenges in GI tract for efficient treatment of diabetes mellitus.
WOS关键词PANCREATIC BETA-CELL ; MESOPOROUS SILICA NANOPARTICLES ; INTESTINAL PERMEATION ENHANCERS ; SELF-ASSEMBLED NANOPARTICLES ; CHITOSAN NANOPARTICLES ; FUNCTIONALIZED NANOPARTICLES ; POLYMERIC NANOPARTICLES ; LOADED NANOPARTICLES ; SURFACE-CHEMISTRY ; DIFFUSION BARRIER
资助项目National Natural Science Foundation of China[32071391] ; National Natural Science Foundation of China[21905283] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; National Natural Science Foundation of China[52073287] ; National Natural Science Foundation of China[22075289] ; Fundamental Research Funds for the Central Universities[06500230] ; Beijing Nova Program[Z201100006820140]
WOS研究方向Engineering ; Materials Science
语种英语
出版者KEAI PUBLISHING LTD
WOS记录号WOS:000789663900001
资助机构National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Beijing Nova Program
源URL[http://ir.ipe.ac.cn/handle/122111/53064]  
专题中国科学院过程工程研究所
通讯作者Li, Yan; Zhang, Xin
作者单位1.Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Li, Yan,Zhang, Wen,Zhao, Ruichen,et al. Advances in oral peptide drug nanoparticles for diabetes mellitus treatment[J]. BIOACTIVE MATERIALS,2022,15:392-408.
APA Li, Yan,Zhang, Wen,Zhao, Ruichen,&Zhang, Xin.(2022).Advances in oral peptide drug nanoparticles for diabetes mellitus treatment.BIOACTIVE MATERIALS,15,392-408.
MLA Li, Yan,et al."Advances in oral peptide drug nanoparticles for diabetes mellitus treatment".BIOACTIVE MATERIALS 15(2022):392-408.

入库方式： OAI收割

来源：过程工程研究所

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