Acid-Sensitive Nanoparticles Based on Molybdenum Disulfide for Photothermal-Chemo Therapy br
文献类型：期刊论文
| 作者 | Liu, Qin1; Song, Ping1; Zhang, Weiwei1; Wang, Zhenyu1; Yang, Kai2,3; Luo, Jianquan4; Zhu, Longbao1; Gui, Lin5; Tao, Yugui1; Ge, Fei1 |
| 刊名 | ACS BIOMATERIALS SCIENCE & ENGINEERING
 |
| 出版日期 | 2022-04-11 |
| 卷号 | 8期号:4页码:1706-1716 |
| ISSN号 | 2373-9878 |
| 关键词 | molybdenum disulfide (MoS2) nanoparticles manganese dioxide (MnO2) DOX photothermal-chemo antitumor therapy |
| DOI | 10.1021/acsbiomaterials.1c01390 |
| 英文摘要 | The combination of multiple treatments hasrecently been investigated for tumor treatment. In this study,molybdenum disulfide (MoS2) with excellent photothermalconversion performance was used as the core, and manganesedioxide (MnO2), which responds to the tumor microenvironment,was loaded on its surface by liquid deposition to form amesoporous core-shell structure. Then, the chemotherapeuticdrug Adriamycin (DOX) was loaded into the hole. To furtherenhance its water solubility and stability, the surface of MnO2wasmodified with mPEG-NH2to prepare the combined antitumornanocomposite MoS2@DOX/MnO2-PEG (MDMP). The resultsshowed that MDMP had a diameter of about 236 nm, itsphotothermal conversion efficiency was 33.7%, and the loading andrelease rates of DOX were 13 and 65%, respectively. Duringin vivoandin vitrostudies, MDMP showed excellent antitumor activity.Under the combined treatment, the tumor cell viability rate was only 11.8%. This nanocomposite exhibits considerable potential forchemo-photothermal combined antitumor therapy |
| WOS关键词 | TUMOR-MICROENVIRONMENT ; DRUG-DELIVERY ; NANO-PLATFORM ; MOS2 ; NANOSHEETS ; GRAPHENE ; MNO2 |
| 资助项目 | National natural science foundation of China[31671797] ; Anhui Nature Science Foundation[1808085QC85] ; Anhui Nature Science Foundation[2008085QH397] ; Anhui Provincial Higher Education Institutes[KJ2020a0375] ; Anhui Polytechnic University[xjky2020064] ; Natural Science Foundation of Anhui University[KJ2020A118] ; Youth Key Talents Program of Wannan Medical College ; Talents Program of Wannan Medical College[wyqnyx202005] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000789105600028 |
| 资助机构 | National natural science foundation of China ; Anhui Nature Science Foundation ; Anhui Provincial Higher Education Institutes ; Anhui Polytechnic University ; Natural Science Foundation of Anhui University ; Youth Key Talents Program of Wannan Medical College ; Talents Program of Wannan Medical College |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/53083]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Zhu, Longbao; Gui, Lin; Tao, Yugui; Ge, Fei |
| 作者单位 | 1.Anhui Polytech Univ, Sch Biol & Food Engn, Wuhu 241000, Anhui, Peoples R China 2.Soochow Univ, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Sch Radiat Med & Protect, State Key Lab Radiat Med & Protect, Suzhou 215123, Jiangsu, Peoples R China 3.Soochow Univ, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou 215123, Jiangsu, Peoples R China 4.Univ Chinese Acad Sci, Inst Proc Engn, Beijing 100049, Peoples R China 5.Wannan Med Coll, Dept Microbiol & Immunol, Wuhu 241002, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Qin,Song, Ping,Zhang, Weiwei,et al. Acid-Sensitive Nanoparticles Based on Molybdenum Disulfide for Photothermal-Chemo Therapy br[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2022,8(4):1706-1716. |
| APA | Liu, Qin.,Song, Ping.,Zhang, Weiwei.,Wang, Zhenyu.,Yang, Kai.,...&Ge, Fei.(2022).Acid-Sensitive Nanoparticles Based on Molybdenum Disulfide for Photothermal-Chemo Therapy br.ACS BIOMATERIALS SCIENCE & ENGINEERING,8(4),1706-1716. |
| MLA | Liu, Qin,et al."Acid-Sensitive Nanoparticles Based on Molybdenum Disulfide for Photothermal-Chemo Therapy br".ACS BIOMATERIALS SCIENCE & ENGINEERING 8.4(2022):1706-1716. |
入库方式： OAI收割
来源：过程工程研究所
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