Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals
文献类型：期刊论文
| 作者 | Ma, Xiaoyan1,2; Gong, Haoning2; Ogino, Kenji1; Yan, Xuehai2,3; Xing, Ruirui2,3 |
| 刊名 | BEILSTEIN JOURNAL OF NANOTECHNOLOGY
 |
| 出版日期 | 2022-03-01 |
| 卷号 | 13页码:284-291 |
| ISSN号 | 2190-4286 |
| 关键词 | antioxidant co-assembly glutathione myricetin nanoarchitectonics |
| DOI | 10.3762/bjnano.13.23 |
| 英文摘要 | Oxidative stress can lead to permanent and irreversible damage to cellular components and even cause cancer and other diseases. Therefore, the development of antioxidative reagents is an important strategy to alleviate chronic diseases and maintain the redox balance in cells. Small-molecule bioactive compounds have exhibited huge therapeutic potential as antioxidants and anti-inflammatory agents. Myricetin (Myr), a well-known natural flavonoid, has drawn wide attention because of its high antioxidant, anti-inflammatory, antimicrobial, and anticancer efficacy. Especially regarding antioxidation, Myr is capable of not only chelating intracellular transition metal ions for removing reactive oxygen species, but also of activating antioxidant enzymes and related signal pathways and, thus, of sustainably scavenging radicals. However, Myr is poorly soluble in water, which limits its bioavailability for biomedical applications, and even its clinical therapeutic potential. The antioxidant peptide glutathione (GSH) plays a role as antioxidant in cells and possesses good hydrophilicity and biocompatibility. However, it is easily metabolized by enzymes. To take advantages of their antioxidation activity and to overcome the abovementioned limitations, GSH, Zn2+, and Myr were selected to co-assemble into Myr-Zn2+-GSH nanoparticles or nanoarchitectonics. This study offers a new design to harness stable, sustainable antioxidant nanoparticles with high loading capacity, high bioavailability, and good biocompatibility as antioxidants. |
| WOS关键词 | OXIDATIVE STRESS ; NANOPARTICLES ; ANTIOXIDANT ; DELIVERY ; STABILITY |
| 资助项目 | Innovation Research Community Science Fund of China[21821005] ; National Natural Science Foundation of China[22072154] ; National Natural Science Foundation of China[21977095] ; Key Research Program of Fron-tier Sciences of Chinese Academy of Sciences (CAS)[QYZDB-SSWJSC034] ; National Natural Science Foun-dation of Hebei Province[B2020103025] |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | BEILSTEIN-INSTITUT |
| WOS记录号 | WOS:000789106300001 |
| 资助机构 | Innovation Research Community Science Fund of China ; National Natural Science Foundation of China ; Key Research Program of Fron-tier Sciences of Chinese Academy of Sciences (CAS) ; National Natural Science Foun-dation of Hebei Province |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/53167]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Ogino, Kenji; Xing, Ruirui |
| 作者单位 | 1.Tokyo Univ Agr & Technol, Grad Sch Bioapplicat & Syst Engn, Tokyo, Japan 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Xiaoyan,Gong, Haoning,Ogino, Kenji,et al. Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals[J]. BEILSTEIN JOURNAL OF NANOTECHNOLOGY,2022,13:284-291. |
| APA | Ma, Xiaoyan,Gong, Haoning,Ogino, Kenji,Yan, Xuehai,&Xing, Ruirui.(2022).Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals.BEILSTEIN JOURNAL OF NANOTECHNOLOGY,13,284-291. |
| MLA | Ma, Xiaoyan,et al."Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals".BEILSTEIN JOURNAL OF NANOTECHNOLOGY 13(2022):284-291. |
入库方式： OAI收割
来源：过程工程研究所
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