Bioinspired Phosphorylcholine Coating for Surface Functionalization of Interventional Biomedical Implants with Bacterial Resistance and Anti-Encrustation Properties br
文献类型：期刊论文
| 作者 | Qian, Yifu2,3; Zhao, Jing4; Liu, Long2; Hu, Hao1; Wang, Bo5; Zhang, Hongyu3 |
| 刊名 | LANGMUIR
 |
| 出版日期 | 2022-03-22 |
| 卷号 | 38期号:11页码:3597-3606 |
| ISSN号 | 0743-7463 |
| DOI | 10.1021/acs.langmuir.2c00263 |
| 通讯作者 | Hu, Hao(huhao@bjmu.edu.cn) ; Wang, Bo(wb@sdust.edu.cn) ; Zhang, Hongyu(zhanghyu@tsinghua.edu.cn) |
| 英文摘要 | Enhancing the lubrication property and bacterialresistance is extremely important for interventional biomedicalimplants to avoid soft tissue damage and biofilm formation. In this study, a zwitterionic phosphorylcholine coating (PMPC) was successfully developed to achieve surface functionalization of apolyurethane (PU)-based ureteral stent via subsurface"graftingfrom"photopolymerization. Typical surface characterizations suchas Fourier transform infrared spectroscopy, X-ray photoelectronspectroscopy, and surface wettability and morphology analysesexamined by scanning electron microscopy, atomic forcemicroscopy, and transmission electron microscopy demonstratedthat the phosphorylcholine polymer was grafted on the substratewith a thickness of 180 nm. Additionally, the tribological experiment performed by a universal material tester showed that thelubrication performance of PU-PMPC was significantly improved compared with that of PU. Thein vitroexperiments indicated thatthe PMPC coating was biocompatible and stably modified on the surface of the substrate with an excellent bacterial resistance rate of>90%. Furthermore, the result of thein vivoexperiment showed that the anti-encrustation performance of the surface-functionalizedureteral stent was better than that of the bare ureteral stent. The great enhancement in the lubrication, bacterial resistance, and anti-encrustation properties of the phosphorylcholine coating was thought to be due to the hydration effects of the zwitterionic charges. In summary, the bioinspired zwitterionic phosphorylcholine coating developed herein achieved significantly improved lubrication, bacterial resistance, and anti-encrustation performances and could be used as a convenient approach for surface functionalization of interventional biomedical implants |
| 资助项目 | National Natural Science Foundation of China[52022043] ; Capital's Funds for Health Improvement and Research, China[2020-2Z-40810] ; Precision Medicine Foundation, Tsinghua University, China[10001020120] ; Liaoning Science and Technology Program[2020JH2/10300159] ; Research Fund of State Key Laboratory of Tribology, Tsinghua University, China[SKLT2022C18] |
| WOS研究方向 | Chemistry ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000778529600027 |
| 资助机构 | National Natural Science Foundation of China ; Capital's Funds for Health Improvement and Research, China ; Precision Medicine Foundation, Tsinghua University, China ; Liaoning Science and Technology Program ; Research Fund of State Key Laboratory of Tribology, Tsinghua University, China |
| 源URL | [http://ir.imr.ac.cn/handle/321006/172963]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Hu, Hao; Wang, Bo; Zhang, Hongyu |
| 作者单位 | 1.Peking Univ Peoples Hosp, Dept Urol, Beijing 100044, Peoples R China 2.Hainan Univ, Sch Chem Engn & Technol, Haikou 570228, Hainan, Peoples R China 3.Tsinghua Univ, Dept Mech Engn, State Key Lab Tribol, Beijing 100084, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 5.Shandong Univ Sci & Technol, Sch Chem & Biol Engn, Qingdao 266590, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qian, Yifu,Zhao, Jing,Liu, Long,et al. Bioinspired Phosphorylcholine Coating for Surface Functionalization of Interventional Biomedical Implants with Bacterial Resistance and Anti-Encrustation Properties br[J]. LANGMUIR,2022,38(11):3597-3606. |
| APA | Qian, Yifu,Zhao, Jing,Liu, Long,Hu, Hao,Wang, Bo,&Zhang, Hongyu.(2022).Bioinspired Phosphorylcholine Coating for Surface Functionalization of Interventional Biomedical Implants with Bacterial Resistance and Anti-Encrustation Properties br.LANGMUIR,38(11),3597-3606. |
| MLA | Qian, Yifu,et al."Bioinspired Phosphorylcholine Coating for Surface Functionalization of Interventional Biomedical Implants with Bacterial Resistance and Anti-Encrustation Properties br".LANGMUIR 38.11(2022):3597-3606. |
入库方式： OAI收割
来源：金属研究所
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