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Antibacterial and anti-inflammatory activities of chitosan/copper complex coating on medical catheters: In vitro and in vivo

文献类型：期刊论文

作者Gu, Guisong4,5; Erisen, Deniz Eren4,6; Yang, Ke4; Zhang, Bingchun4; Shen, Minggang5; Zou, Jingyu1; Qi, Xun2; Chen, Shanshan4; Xu, Xiaohe3
刊名JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
出版日期2022-03-07
页码12
ISSN号1552-4973
关键词antibacterial catheter chitosan copper ion inflammation
DOI10.1002/jbm.b.35047
通讯作者Chen, Shanshan(sschen@imr.ac.cn) ; Xu, Xiaohe(32626292@qq.com)
英文摘要Copper ions (Cu) grafted chitosan coating was prepared using the pneumatic spraying method on the silicone rubber surface. Coating's surface properties, morphology, composition, Cu releasing behavior, antibacterial, and anti-inflammatory activities are investigated and discussed. Surface properties, composition, and morphology were investigated by scanning electron microscopy (SEM) and contact angle measurements. The antibacterial activity has been tested with Escherichia coli and Staphylococcus aureus suspensions in vitro. Besides, the morphology of the biofilm was inspected with a field emission SEM. To evaluate the anti-inflammatory activity and biosafety of the coating in vivo, the optimized coating samples and control groups were implanted subcutaneously into the back of mice. The bacterial environment model was established by injection of the bacterial suspension. The morphology and bacterial adhered on the surface of catheters and the surrounding tissues were analyzed after 5 days of implantation. As in vitro results, the number of adhered bacterial on the surface of the silicon rubber surface was decreased, and the anti-inflammatory rate was increased by the intensify of the Cu content in chitosan coating. As for in vivo results, after 5 days of implantation, there was no evident inflammation in the surrounding tissues of all catheters in all without the S. aureus injected group. In the injected chitosan/Cu coated group; the inflammation, the number of the adhered bacteria were observed less than other injected samples without Cu; no inflammation were noticeable. Results indicate that the Cu-modified chitosan coating can confer excellent antibacterial and anti-inflammatory activity as applied on medical catheters.
资助项目Doctoral Start-up Foundation of Liaoning Province[2019-BS-293] ; National Key Research and Development Program of China[2018YFC1105504] ; National Natural Science Foundation of China[51901227] ; National Natural Science Foundation of China[81701048] ; National Natural Science Foundation of China[81873918] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2019194]
WOS研究方向Engineering ; Materials Science
语种英语
出版者WILEY
WOS记录号WOS:000765366900001
资助机构Doctoral Start-up Foundation of Liaoning Province ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences
源URL[http://ir.imr.ac.cn/handle/321006/173240]  
专题金属研究所_中国科学院金属研究所
通讯作者Chen, Shanshan; Xu, Xiaohe
作者单位1.China Med Univ, Dept Neurosurg, Affiliated Hosp 1, Shenyang, Peoples R China
2.China Med Univ, Dept Radiol, Affiliated Hosp 1, Key Lab Diagnost Imaging & Intervent Radiol Liaon, Shenyang, Peoples R China
3.China Med Univ, Dept Ophthalmol, Shengjing Hosp, 36 Sanhao St, Shenyang 110001, Peoples R China
4.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China
5.Univ Sci & Technol Liaoning, Sch Mat & Met, Anshan, Peoples R China
6.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Gu, Guisong,Erisen, Deniz Eren,Yang, Ke,et al. Antibacterial and anti-inflammatory activities of chitosan/copper complex coating on medical catheters: In vitro and in vivo[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,2022:12.
APA Gu, Guisong.,Erisen, Deniz Eren.,Yang, Ke.,Zhang, Bingchun.,Shen, Minggang.,...&Xu, Xiaohe.(2022).Antibacterial and anti-inflammatory activities of chitosan/copper complex coating on medical catheters: In vitro and in vivo.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,12.
MLA Gu, Guisong,et al."Antibacterial and anti-inflammatory activities of chitosan/copper complex coating on medical catheters: In vitro and in vivo".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2022):12.

入库方式： OAI收割

来源：金属研究所

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