Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration
文献类型：期刊论文
| 作者 | Chang, Peng3; Zhang, Wenchang4; Wu, Mi4; Zou, Rufei4; Song, Xiaoqiang1; Sun, Qian2; Gao, Junqing5; Zhao, Yan4; Liu, Yunhui3 |
| 刊名 | MACROMOLECULAR BIOSCIENCE
 |
| 出版日期 | 2022-01-12 |
| 页码 | 10 |
| 关键词 | chitosan gelatin minimal functional unit of skin (MFUS) tissue-engineered skin wound healing |
| ISSN号 | 1616-5187 |
| DOI | 10.1002/mabi.202100419 |
| 通讯作者 | Chang, Peng(cp17625@163.com) ; Gao, Junqing(gao-7950@163.com) ; Zhao, Yan(zhaoyan@jihualab.com) ; Liu, Yunhui(liuyh@sj-hospital.org) |
| 英文摘要 | The construction of intact functional skin is a challenging field in tissue engineering. Traditional skin tissue engineering, using "seed cells" as a bioactive source for scaffolding materials maybe not efficient enough. Here a new strategy is shown for constructing functional tissue-engineered skin with Minimal Functional Unit of Skin (MFUS) as the source of bioactivity. Chitosan/gelatin non-woven fabric is used as the scaffold. MFUS is derived from autologous skin with full-thickness skin microstructure and complete functional skin unit harvesting. A mathematical model is used to calculate the MFUS Minimal Harvest Diameter and Angle (MHDA). Chitosan/gelatin non-woven fabric (CS+GEL) is porous and absorbable, with an elastic modulus meeting the requirement of skin engineering. It supports layered and 3D growth of MFUS. The degradation rate of chitosan, including filament diameter and density is evaluated in vivo. MFUS-engineered skin could reduce the density of local nerve fibers in the early stage, potentially reducing pain during wound healing, as well as could limit excessive fibroblast cell migration in the later stage, potentially reducing scar formation. This study proposes a new strategy for the clinical treatment of large full-thickness skin defects by constructing intact functional at minimal cost. |
| 资助项目 | Shenyang Science and Technology Bureau[19-109-4-02] ; Shenyang Science and Technology Bureau[21-172-9-15] ; Guangdong Climbing Peaks Program for High-level Hospital Development[202000240] ; Science & Technology Department of Liaoning Province[2021-KF-22-16] ; State Key Laboratory of Robotics, China[2021-KF-22-16] ; Shengjing Hospital 345 Talent Project |
| WOS研究方向 | Biochemistry & Molecular Biology ; Materials Science ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000741940000001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | Shenyang Science and Technology Bureau ; Guangdong Climbing Peaks Program for High-level Hospital Development ; Science & Technology Department of Liaoning Province ; State Key Laboratory of Robotics, China ; Shengjing Hospital 345 Talent Project |
| 源URL | [http://ir.imr.ac.cn/handle/321006/173733]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Chang, Peng; Gao, Junqing; Zhao, Yan; Liu, Yunhui |
| 作者单位 | 1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.Gen Hosp Northern Ctr Command, Expt Anim Ctr, Shenyang 110084, Peoples R China 3.China Med Univ, Shengjing Hosp, Dept Plast & Reconstruct & Neurosurg Surg, Shenyang 110004, Peoples R China 4.Jihua Lab, Foshan 528000, Peoples R China 5.Foshan Hosp Tradit Chinese Med, Foshan 528000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chang, Peng,Zhang, Wenchang,Wu, Mi,et al. Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration[J]. MACROMOLECULAR BIOSCIENCE,2022:10. |
| APA | Chang, Peng.,Zhang, Wenchang.,Wu, Mi.,Zou, Rufei.,Song, Xiaoqiang.,...&Liu, Yunhui.(2022).Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration.MACROMOLECULAR BIOSCIENCE,10. |
| MLA | Chang, Peng,et al."Chitosan/Gelatin Composite Nonwoven Fabric Scaffold Seeding Minimal Function Unit of Skin for Functional Skin Regeneration".MACROMOLECULAR BIOSCIENCE (2022):10. |
入库方式： OAI收割
来源：金属研究所
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