Regio-selective Reduction of Oxysophoridine by Microorganism Isolated from Soil
文献类型：期刊论文
| 作者 | Fu, Shaobin; Li, Yi; Meng, Qingfeng1; Yue, Changwu5; Sun, Yongzhen4; Wei, Gang3 |
| 刊名 | JOURNAL OF THE CHINESE CHEMICAL SOCIETY
 |
| 出版日期 | 2016 |
| 卷号 | 63期号:4页码:331-335 |
| 关键词 | Biocatalysis Region-stereoselectivity Soil microbes Natural product Condition optimization |
| ISSN号 | 0009-4536 |
| DOI | 10.1002/jccs.201500501 |
| 文献子类 | Article |
| 英文摘要 | Oxysophoridine (OSR), an alkaloid extracted from a traditional Chinese medicine, attracted more and more attention because of remarkable biological activities. Biocatalysis of OSR by 86 stains including soil microbes and endophytic fungi were investigated. Incubation of OSR with soil bacteria T003 identified as Escherichia coli could lead to only one reductive product with highly regio-selectivity. The structural elucidations of transformation product were achieved mainly by the NMR spectroscopic methods and references. Effect of pH, substrate concentration, conversion time and strain concentration was studied, the optimization of reaction was analyzed by LC-MS. The production of sophoridine (SR) from OSR was highest at pH 7.0, 36 h of incubation and in presence of 625 mu g/mL substrate concentration, 50 mu L/mL strain concentration respectively. Biocatalysis was considered the alternatives to preparation of sophoridine with green and sustainable synthetic processes except for less time-consuming and more environmentally friendly. |
| 学科主题 | Chemistry, Multidisciplinary |
| 出版地 | WEINHEIM |
| 电子版国际标准刊号 | 2192-6549 |
| WOS关键词 | MICE ; EXPRESSION |
| WOS研究方向 | Science Citation Index Expanded (SCI-EXPANDED) |
| 语种 | 英语 |
| WOS记录号 | WOS:000375554200003 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21462057] ; Program of Ministry of Education Chunhui Plan [Z2014091] ; Guizhou Science and Technology Department [QKHLH-2014-7555] ; Program for Guizhou Key Laboratory of Microbial Resources & Drug Development [GZMRD-2014-003] ; Ntional Training Program of Innovation and Entrepreneurship for Undergraduates [201410661013] |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/24976]  |
| 专题 | 中科院植物分子生理学重点实验室 |
| 作者单位 | 1.Zunyi Med Coll, Dept Pharm, Zunyi 563000, Peoples R China 2.CSIRO, Mat Sci & Engn, Sydney 2070, NSW, Australia 3.Chinese Acad Sci, Inst Bot, Beijing 100093, Peoples R China 4.Zunyi Med Coll, Guizhou Key Lab Microbial Resources & Drug Dev, Zunyi 563003, Peoples R China 5.Zunyi Med Coll, Dept Publ Hlth, Zunyi 563000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Shaobin,Li, Yi,Meng, Qingfeng,et al. Regio-selective Reduction of Oxysophoridine by Microorganism Isolated from Soil[J]. JOURNAL OF THE CHINESE CHEMICAL SOCIETY,2016,63(4):331-335. |
| APA | Fu, Shaobin,Li, Yi,Meng, Qingfeng,Yue, Changwu,Sun, Yongzhen,&Wei, Gang.(2016).Regio-selective Reduction of Oxysophoridine by Microorganism Isolated from Soil.JOURNAL OF THE CHINESE CHEMICAL SOCIETY,63(4),331-335. |
| MLA | Fu, Shaobin,et al."Regio-selective Reduction of Oxysophoridine by Microorganism Isolated from Soil".JOURNAL OF THE CHINESE CHEMICAL SOCIETY 63.4(2016):331-335. |
入库方式： OAI收割
来源：植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。