Hypomagnetic Field Induces the Production of Reactive Oxygen Species and Cognitive Deficits in Mice Hippocampus
文献类型：期刊论文
| 作者 | Tian, Lanxiang1,2,3; Luo, Yukai1,2,4; Zhan, Aisheng1,2,4; Ren, Jie1,2,4; Qin, Huafeng2,3; Pan, Yongxin1,2,3,4 |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2022-04-01 |
| 卷号 | 23期号:7页码:12 |
| 关键词 | hypomagnetic field cognitive dysfunction hippocampus reactive oxygen species redox balance gene expression oxidative stress |
| DOI | 10.3390/ijms23073622 |
| 英文摘要 | Previous studies have found that hypomagnetic field (HMF) exposure impairs cognition behaviors in animals; however, the underlying neural mechanisms of cognitive dysfunction are unclear. The hippocampus plays important roles in magnetoreception, memory, and spatial navigation in mammals. Therefore, the hippocampus may be the key region in the brain to reveal its neural mechanisms. We recently reported that long-term HMF exposure impairs adult hippocampal neurogenesis and cognition through reducing endogenous reactive oxygen species (ROS) levels in adult neural stem cells that are confined in the subgranular zone (SGZ) of the hippocampus. In addition to adult neural stem cells, the redox state of other cells in the hippocampus is also an important factor affecting the functions of the hippocampus. However, it is unclear whether and how long-term HMF exposure affects ROS levels in the entire hippocampus (i.e., the dentate gyrus (DG) and ammonia horn (CA) regions). Here, we demonstrate that male C57BL/6J mice exposed to 8-week HMF exhibit cognitive impairments. We then found that the ROS levels of the hippocampus were significantly higher in these HMF-exposed mice than in the geomagnetic field (GMF) group. PCR array analysis revealed that the elevated ROS levels were due to HMF-regulating genes that maintain the redox balance in vivo, such as Nox4, Gpx3. Since high levels of ROS may cause hippocampal oxidative stress, we suggest that this is another reason why HMF exposure induces cognitive impairment, besides the hippocampal neurogenesis impairments. Our study further demonstrates that GMF plays an important role in maintaining hippocampal function by regulating the appropriate endogenous ROS levels. |
| WOS关键词 | OXIDATIVE STRESS ; HYDROGEN-PEROXIDE ; DENTATE GYRUS ; NITRIC-OXIDE ; STEM-CELLS ; ROS ; SPACE ; DYSFUNCTION ; MECHANISMS ; NAVIGATION |
| 资助项目 | National Natural Science Foundation of China[42074073] ; National Natural Science Foundation of China[41621004] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA17010501] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000781159800001 |
| 出版者 | MDPI |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences |
| 源URL | [http://ir.iggcas.ac.cn/handle/132A11/105081]  |
| 专题 | 地质与地球物理研究所_中国科学院地球与行星物理重点实验室 |
| 通讯作者 | Tian, Lanxiang |
| 作者单位 | 1.Chinese Acad Sci, Inst Geol & Geophys, Key Lab Earth & Planetary Phys, Biogeomagnetism Grp, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Innovat Acad Earth Sci, Beijing 100029, Peoples R China 3.Chinese Acad Sci, Inst Geol & Geophys, Paleomagnetism & Geochronol Lab, Beijing 100029, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, Lanxiang,Luo, Yukai,Zhan, Aisheng,et al. Hypomagnetic Field Induces the Production of Reactive Oxygen Species and Cognitive Deficits in Mice Hippocampus[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(7):12. |
| APA | Tian, Lanxiang,Luo, Yukai,Zhan, Aisheng,Ren, Jie,Qin, Huafeng,&Pan, Yongxin.(2022).Hypomagnetic Field Induces the Production of Reactive Oxygen Species and Cognitive Deficits in Mice Hippocampus.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(7),12. |
| MLA | Tian, Lanxiang,et al."Hypomagnetic Field Induces the Production of Reactive Oxygen Species and Cognitive Deficits in Mice Hippocampus".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.7(2022):12. |
入库方式： OAI收割
来源：地质与地球物理研究所
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