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  2. 地质与地球物理研究所
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  4. 中国科学院地球与行星物理重点实验室
Enhanced Magnetic Hyperthermia of Magnetoferritin through Synthesis at Elevated Temperature

文献类型：期刊论文

作者Yu, Jiacheng1,2; Cao, Changqian1,2; Fang, Fengjiao1,2,3; Pan, Yongxin1,2,3
刊名INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
出版日期2022-04-01
卷号23期号:7页码:15
关键词hyperthermophilic archaeon iron oxide nanoparticle magnetic hyperthermia magnetoferritin biomineralization
DOI10.3390/ijms23074012
英文摘要Iron oxide nanoparticles have attracted a great deal of research interest in recent years for magnetic hyperthermia therapy owing to their biocompatibility and superior thermal conversion efficiency. Magnetoferritin is a type of biomimetic superparamagnetic iron oxide nanoparticle in a ferritin cage with good monodispersity, biocompatibility, and natural hydrophilicity. However, the magnetic hyperthermic efficiency of this kind of nanoparticle is limited by the small size of the mineral core as well as its low synthesis temperature. Here, we synthesized a novel magnetoferritin particle by using a recombinant ferritin from the hyperthermophilic archaeon Pyrococcus furiosus as a template with high iron atom loading of 9517 under a designated temperature of 90 degrees C. Compared with the magnetoferritins synthesized at 45 and 65 degrees C, the one synthesized at 90 degrees C displays a larger average magnetite and/or maghemite core size of 10.3 nm. This yields an increased saturation magnetization of up to 49.6 emu g(-1) and an enhanced specific absorption rate (SAR) of 805.3 W g(-1) in an alternating magnetic field of 485.7 kHz and 49 kA m(-1). The maximum intrinsic loss power (ILP) value is 1.36 nHm(2) kg(-1). These results provide new insights into the biomimetic synthesis of magnetoferritins with enhanced hyperthermic efficiency and demonstrate the potential application of magnetoferritin in the magnetic hyperthermia of tumors.
WOS关键词OXIDE-BASED NANOPARTICLES ; FE3O4 NANOPARTICLES ; CANCER-CELLS ; FERRITIN ; ABSORPTION ; REDUCTION ; NANOCUBES ; PROTEIN ; FLUID
资助项目National Natural Science Foundation of China[41774076] ; National Natural Science Foundation of China[41621004] ; Key Research Program of the Institute of Geology and Geophysics, CAS[IGGCAS-201903] ; PetroChina Innovation Foundation[2020D-5007-0105]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000781323300001
出版者MDPI
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation
源URL[http://ir.iggcas.ac.cn/handle/132A11/105094]  
专题地质与地球物理研究所_中国科学院地球与行星物理重点实验室
通讯作者Cao, Changqian
作者单位1.Chinese Acad Sci, Inst Geol & Geophys, Key Lab Earth & Planetary Phys, Beijing 100029, Peoples R China
2.Chinese Acad Sci, Innovat Acad Earth Sci, Beijing 100029, Peoples R China
3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Yu, Jiacheng,Cao, Changqian,Fang, Fengjiao,et al. Enhanced Magnetic Hyperthermia of Magnetoferritin through Synthesis at Elevated Temperature[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(7):15.
APA Yu, Jiacheng,Cao, Changqian,Fang, Fengjiao,&Pan, Yongxin.(2022).Enhanced Magnetic Hyperthermia of Magnetoferritin through Synthesis at Elevated Temperature.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(7),15.
MLA Yu, Jiacheng,et al."Enhanced Magnetic Hyperthermia of Magnetoferritin through Synthesis at Elevated Temperature".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.7(2022):15.

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来源：地质与地球物理研究所

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