18F-FDG and 68?Ga-FAPI PET/CT for the evaluation of periprosthetic joint infection and aseptic loosening in rabbit models
文献类型：期刊论文
| 作者 | Wang,Yiqun6; Li,Yu4,5; Han,Liang3; Wang,Jun4,5 ; Zhang,Cong6; Qi,Erpeng2; Zhang,Dongyun2; Zhang,Xiaojun6; Huan,Yong1,4,5; Tian,Jiahe6
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| 刊名 | BMC Musculoskeletal Disorders
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| 出版日期 | 2022-06-20 |
| 卷号 | 23期号:1 |
| 关键词 | Periprosthetic joint infection Aseptic loosening 18F-FDG 68?Ga-FAPI Rabbit model |
| DOI | 10.1186/s12891-022-05537-w |
| 通讯作者 | Zhang,Xiaojun(345929778@qq.com) ; Huan,Yong(huany@lnm.imech.ac.cn) ; Tian,Jiahe(www9299sss@163.com) |
| 英文摘要 | AbstractPurposeWe built a joint replacement loosening model based on the original rabbit model of infection and evaluated the performance characteristics of 18F-FDG and 68?Ga-FAPI in evaluating infection and loosening.MethodsAfter surgery, the rabbits were divided into four groups, with six individuals in the control group and 10 each in the aseptic loosening, S. aureus and S. epidermidis groups. PET/CT and serological examination were performed three times at two-week intervals. After the rabbits were euthanized, micro-CT, tissue pathology, pullout tests and scanning electron microscopy (SEM) were performed.ResultsThe pullout test and SEM showed the feasibility of the aseptic loosening model. 18F-FDG showed similar performance in the control and loosening groups. The SUVmax of the S. aureus group was consistently higher than that of the S. epidermidis group. As for 68?Ga-FAPI, the SUVmax of the control group was lowest in the second week and gradually increased over subsequent weeks. The SUVmax of the loosening group began to exceed that of the control group after the second week. The SUVmax of the S. aureus group in the second week was the lowest among the four groups and increased as the number of weeks increased. The pathology results showed concordance with the performance of PET/CT. Linear regressions between SUVmax and serology showed that 18F-FDG was positively correlated with CRP and IL-6, while 68?Ga-FAPI revealed negative correlations with CRP and IL-6 in the second week and positive correlations in the sixth week. In addition, the SUVmax and MT(target)V of both 18F-FDG and 68?Ga-FAPI were negatively correlated with bone volume/trabecular volume (TV) and bone surface area/TV.ConclusionIn this longitudinal observation, 68?Ga-FAPI showed greater sensitivity than 18F-FDG in detecting diseases, and 68?Ga-FAPI had no intestinal or muscular uptake. The MT(target)V of 68?Ga-FAPI was larger than that of 18F-FDG, which meant that 68?Ga-FAPI had the potential to define the scope of lesions more accurately. Finally, the SUVmax of 68?Ga-FAPI could not differentiate between loosening and infection; further study of the diagnostic criteria is warranted. |
| 语种 | 英语 |
| WOS记录号 | BMC:10.1186/S12891-022-05537-W |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/89660]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 通讯作者 | Zhang,Xiaojun; Huan,Yong; Tian,Jiahe |
| 作者单位 | 1.Chinese Academy of Sciences; Beijing Key Laboratory of Engineered Construction and Mechanobiology, Institute of Mechanics 2.Chinese PLA General Hospital; Department of Interventional Ultrasound, The First Medical Centre 3.China-Japan Union Hospital of Jilin University; Department of Pathology 4.University of Chinese Academy of Sciences; School of Engineering Science 5.Chinese Academy of Sciences; State Key Laboratory of Nonlinear Mechanics (LNM), Institute of Mechanics 6.Chinese PLA General Hospital; Department of Nuclear Medicine, The First Medical Centre |
| 推荐引用方式 GB/T 7714 | Wang,Yiqun,Li,Yu,Han,Liang,et al. 18F-FDG and 68?Ga-FAPI PET/CT for the evaluation of periprosthetic joint infection and aseptic loosening in rabbit models[J]. BMC Musculoskeletal Disorders,2022,23(1). |
| APA | Wang,Yiqun.,Li,Yu.,Han,Liang.,Wang,Jun.,Zhang,Cong.,...&Li Y.(2022).18F-FDG and 68?Ga-FAPI PET/CT for the evaluation of periprosthetic joint infection and aseptic loosening in rabbit models.BMC Musculoskeletal Disorders,23(1). |
| MLA | Wang,Yiqun,et al."18F-FDG and 68?Ga-FAPI PET/CT for the evaluation of periprosthetic joint infection and aseptic loosening in rabbit models".BMC Musculoskeletal Disorders 23.1(2022). |
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来源：力学研究所
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