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Structural changes in selected human proteins induced by exposure to quantum dots, their biological relevance and possible biomedical applications

文献类型：期刊论文

作者Li, Lin -Han3,4; Fan, Hong-Rui1,3,4; Qiu, Zheng-Jie3,4; Yang, Kui-Feng1,3,4; Han, Jian2
刊名NANOIMPACT
出版日期2022-04-01
卷号26页码:17
关键词Quantum dot Protein-quantum dot interaction Protein corona Protein structure Biological response
ISSN号2452-0748
DOI10.1016/j.impact.2022.100405
英文摘要Quantum dots (QDs) are semi-conductor luminescent nanocrystals usually of 2-10 nm diameter, attracting the significant attention in biomedical studies since emerged. Due to their unique optical and electronic properties, i. e. wide absorption spectra, narrow tunable emission bands or stable, bright photoluminescence, QDs seem to be ideally suited for multi-colour, simultaneous bioimaging and cellular labeling at the molecular level as new -generation probes. A highly reactive surface of QDs allows for conjugating them to biomolecules, what en-ables their direct binding to areas of interest inside or outside the cell for biosensing or targeted delivery. Particularly protein-QDs conjugates are current subjects of research, as features of QDs can be combined with protein specific functionalities and therefore used as a complex in variety of biomedical applications. It is known that QDs are able to interact with cells, organelles and macromolecules of the human body after administration. QDs are reported to cause changes at proteins level, including unfolding and three-dimensional structure al -terations which might hamper proteins from performing their physiological functions and thereby limit the use of QD-protein conjugates in vivo. Moreover, these changes may trigger unwanted cellular outcomes as the effect of different signaling pathways activation. In this review, characteristics of QDs interactions with certain human proteins are presented and discussed. Besides that, the following manuscript provides an overview on structural changes of specific proteins exposed to QDs and their biological and biomedical relevance.
WOS关键词STABILIZED GOLD NANOPARTICLES ; BLOOD-BRAIN-BARRIER ; CARBON DOTS ; SURFACE-PROPERTIES ; PLASMA-PROTEINS ; CIRCULAR-DICHROISM ; TIME EVOLUTION ; DRUG-DELIVERY ; BIO-MOLECULES ; CORONA
资助项目Ministry of Education and Science[016/RID/2018/19] ; Ministry of Education and Science[9 354 023,74 PLN] ; Regional Initiative of Excellence?
WOS研究方向Environmental Sciences & Ecology ; Science & Technology - Other Topics
语种英语
WOS记录号WOS:000799355500003
出版者ELSEVIER
资助机构Ministry of Education and Science ; Ministry of Education and Science ; Regional Initiative of Excellence? ; Regional Initiative of Excellence? ; Ministry of Education and Science ; Ministry of Education and Science ; Regional Initiative of Excellence? ; Regional Initiative of Excellence? ; Ministry of Education and Science ; Ministry of Education and Science ; Regional Initiative of Excellence? ; Regional Initiative of Excellence? ; Ministry of Education and Science ; Ministry of Education and Science ; Regional Initiative of Excellence? ; Regional Initiative of Excellence?
源URL[http://ir.iggcas.ac.cn/handle/132A11/105946]  
专题地质与地球物理研究所_中国科学院矿产资源研究重点实验室
通讯作者Fan, Hong-Rui
作者单位1.Chinese Acad Sci, Innovat Acad Earth Sci, Beijing, Peoples R China
2.China Nonferrous Met Min Grp Fushun Hongtoushan CO, LTD, Fushun 113321, Peoples R China
3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing 100049, Peoples R China
4.Inst Geol & Geophys, Chinese Acad Sci, Key Lab Mineral Resources, Beijing 100029, Peoples R China
推荐引用方式
GB/T 7714		 Li, Lin -Han,Fan, Hong-Rui,Qiu, Zheng-Jie,et al. Structural changes in selected human proteins induced by exposure to quantum dots, their biological relevance and possible biomedical applications[J]. NANOIMPACT,2022,26:17.
APA Li, Lin -Han,Fan, Hong-Rui,Qiu, Zheng-Jie,Yang, Kui-Feng,&Han, Jian.(2022).Structural changes in selected human proteins induced by exposure to quantum dots, their biological relevance and possible biomedical applications.NANOIMPACT,26,17.
MLA Li, Lin -Han,et al."Structural changes in selected human proteins induced by exposure to quantum dots, their biological relevance and possible biomedical applications".NANOIMPACT 26(2022):17.

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来源：地质与地球物理研究所

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