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Association of high BMI with subclinical hypothyroidism in young, first-episode and drug-naive patients with major depressive disorder: a large-scale cross-sectional study

文献类型：期刊论文

作者Kang, Chuanyi9; Liu, Jiacheng9; Zheng, Yue6,7,8; Wang, Xiaohong9; Yang, Liying9; Qiu, Siyu5; Zhao, Ying4; Lackey, Blake N.3; Wu, Hanjing Emily3; Zhao, Na9
刊名EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
出版日期2022-05-12
页码8
关键词Obesity Overweight Subclinical hypothyroidism Major depressive disorder First-episode drug naive Youth
ISSN号0940-1334
DOI10.1007/s00406-022-01415-7
通讯作者Zhao, Na(zhaona@hrbmu.edu.cn) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Thyroid dysfunction is known to be associated with obesity, but the reliability of this relationship is easily affected by drug treatment, age, and subclinical hypothyroidism (SCH) with no apparent symptoms. Our research aims to compare obese and overweight BMI ranges with SCH and without SCH in a large sample of young, first-episode and drug-naive (FEDN) patients with major depressive disorder (MDD), which has received little systemic investigation. A total of 1289 FEDN MDD young outpatients were recruited for this study. Serum thyroid function and lipid level parameters were measured; HAMD and PANSS scales were used to assess patients' depression and positive symptoms. A self-administered questionnaire collected other clinical and demographic data. The prevalence of SCH in FEDN MDD young patients was 58.26%. Compared to patients without SCH, the patients with SCH had a more prolonged illness duration, higher BMI levels, increased prevalence of overweight and obesity, higher HAMD score and PANSS-positive symptom scores, higher levels of TG, TC, LDL-C, and lower levels of HDL-C. Further logistic regression indicated that overweight BMI, obese BMI, illness duration, HAMD score, HDL-C, and TC were significantly associated with SCH. Our results indicate that obesity and overweight may be associated with SCH in young, FEDN MDD patients. The importance of regular thyroid function assessment in young FEDN MDD patients with high BMI should be taken into account.
收录类别SCI
WOS关键词BODY-MASS INDEX ; THYROID-FUNCTION ; SEX-DIFFERENCES ; OBESE CHILDREN ; RISK-FACTORS ; AUTOIMMUNITY ; POPULATION ; HORMONE ; ANXIETY ; SYMPTOMS
资助项目research and innovation fund of the First Affiliated Hospital of Harbin Medical University[2020B07]
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
WOS记录号WOS:000793608400001
出版者SPRINGER HEIDELBERG
资助机构research and innovation fund of the First Affiliated Hospital of Harbin Medical University
源URL[http://ir.psych.ac.cn/handle/311026/42674]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhao, Na; Zhang, Xiangyang
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX USA
4.Harbin Med Univ, Dept Lab, Affiliated Hosp 4, Harbin, Heilongjiang, Peoples R China
5.Harbin Med Univ, Dept Gastroenterol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
6.Peking Univ, NHC Key Lab Mental Hlth, Beijing, Peoples R China
7.Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
8.Peking Univ, Inst Mental Hlth, Hosp 6, Beijing, Peoples R China
9.Harbin Med Univ, Dept Psychiat, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
推荐引用方式
GB/T 7714		 Kang, Chuanyi,Liu, Jiacheng,Zheng, Yue,et al. Association of high BMI with subclinical hypothyroidism in young, first-episode and drug-naive patients with major depressive disorder: a large-scale cross-sectional study[J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,2022:8.
APA Kang, Chuanyi.,Liu, Jiacheng.,Zheng, Yue.,Wang, Xiaohong.,Yang, Liying.,...&Zhang, Xiangyang.(2022).Association of high BMI with subclinical hypothyroidism in young, first-episode and drug-naive patients with major depressive disorder: a large-scale cross-sectional study.EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,8.
MLA Kang, Chuanyi,et al."Association of high BMI with subclinical hypothyroidism in young, first-episode and drug-naive patients with major depressive disorder: a large-scale cross-sectional study".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2022):8.

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来源：心理研究所

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