Serum BDNF levels, glycolipid metabolism in deficit schizophrenia: A case-control study
文献类型：期刊论文
| 作者 | Zhu, Xu6; Chen, Dachun5; Xiu, Meihong5; Li, Shen2,6; Zhang, Xiang Yang1,3,4
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| 刊名 | ASIAN JOURNAL OF PSYCHIATRY
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| 出版日期 | 2022-03-01 |
| 卷号 | 69页码:8 |
| 关键词 | Deficit schizophrenia BDNF Metabolism Glucose Lipid |
| ISSN号 | 1876-2018 |
| DOI | 10.1016/j.ajp.2022.103003 |
| 通讯作者 | Li, Shen(lishen@tmu.edu.cn) ; Zhang, Xiang Yang(zhangxy@psych.ac.cn) |
| 英文摘要 | Background: Few studies have compared serum BDNF and glycolipid profiles in patients with deficit schizophrenia (DS) and non-deficit schizophrenia (NDS). We aimed to compare BDNF and glycolipid profiles between DS and NDS patients and healthy controls, and to investigate the relationship between BDNF, glycolipid profiles in DS and NDS patients.& nbsp;Methods: A total of 591 patients with chronic schizophrenia (SZ) and 238 healthy controls participated in this study. According to Proxy for the Deficit Syndrome Scale, SZ patients were divided into DS (n = 158) and NDS (n = 273) patients. Psychiatric symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). Serum BDNF levels were measured using enzyme-linked immunosorbent assay (ELISA).& nbsp;Results: BDNF levels were significantly lower in SZ patients than those in healthy controls (7.81 & PLUSMN; 2.98 ng/ml vs. 11.96 & PLUSMN; 2.29 ng/ml, P < 0.01). Furthermore, BDNF levels were lower in DS group than those in NDS group (P = 0.007, OR = 0.846, 95% CI = 0.750-0.955). Lower triglyceride levels were also an independent predictor for DS patients (P = 0.007, OR = 0.846, 95% CI = 0.750-0.955). Serum BDNF levels were negatively associated with the severity of deficit syndrome in SZ patients (beta =-1.151, t =-2.559, P = 0.011). In DS group, triglycerides were associated with PANSS negative subscore (beta =-0.262, t =-2.994, P = 0.003) and depressive factor subscore (beta = 0.282, t = 2.146, P = 0.035).& nbsp;Conclusion: Serum BDNF and triglycerides may be informative biomarkers of DS in SZ patients. The differences in glycolipid metabolism patterns between DS and NDS patients indicate that deficit syndrome is an independent endophenotype of SZ patients. |
| 收录类别 | SCI |
| WOS关键词 | NEGATIVE SYNDROME SCALE ; NEUROTROPHIC FACTOR ; 1ST-EPISODE SCHIZOPHRENIA ; GLUCOSE-TOLERANCE ; NAIVE PATIENTS ; PSYCHOPATHOLOGY ; IMPAIRMENT ; PREVALENCE ; DISORDERS ; PSYCHOSIS |
| 资助项目 | National Natural Science Foundation of China[81801323] |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000794049000003 |
| 出版者 | ELSEVIER |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.psych.ac.cn/handle/311026/42712]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Li, Shen; Zhang, Xiang Yang |
| 作者单位 | 1.Chinese Acad Sci, Dept Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Tianjin Med Univ, Coll Basic Med Sci, Dept Psychiat & Psychol, 22 Qixiangtai Rd, Tianjin 300070, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 5.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China 6.Tianjin Med Univ, Coll Basic Med Sci, Dept Psychiat & Psychol, Tianjin 300070, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Xu,Chen, Dachun,Xiu, Meihong,et al. Serum BDNF levels, glycolipid metabolism in deficit schizophrenia: A case-control study[J]. ASIAN JOURNAL OF PSYCHIATRY,2022,69:8. |
| APA | Zhu, Xu,Chen, Dachun,Xiu, Meihong,Li, Shen,&Zhang, Xiang Yang.(2022).Serum BDNF levels, glycolipid metabolism in deficit schizophrenia: A case-control study.ASIAN JOURNAL OF PSYCHIATRY,69,8. |
| MLA | Zhu, Xu,et al."Serum BDNF levels, glycolipid metabolism in deficit schizophrenia: A case-control study".ASIAN JOURNAL OF PSYCHIATRY 69(2022):8. |
入库方式： OAI收割
来源：心理研究所
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