Functional lateralization of the medial temporal lobe in novel associative processing during creativity evaluation
文献类型：期刊论文
| 作者 | Ren, Jingyuan8,9; Huang, Furong7; Gao, Chuanji8; Gott, Jarrod8; Schoch, Sarah F.6,8; Qin, Shaozheng1,4,5; Dresler, Martin8; Luo, Jing2,3,9
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| 刊名 | CEREBRAL CORTEX
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| 出版日期 | 2022-03-30 |
| 页码 | 21 |
| 关键词 | medial temporal lobe hippocampus hemispheric lateralization creativity fMRI |
| ISSN号 | 1047-3211 |
| DOI | 10.1093/cercor/bhac129 |
| 通讯作者 | Ren, Jingyuan(jingyuan.ren@donders.ru.nl) ; Luo, Jing(luoj@psych.ac.cn) |
| 英文摘要 | Although hemispheric lateralization of creativity has been a longstanding topic of debate, the underlying neurocognitive mechanism remains poorly understood. Here we designed 2 types of novel stimuli-"novel useful and novel useless," adapted from "familiar useful" designs taken from daily life-to demonstrate how the left and right medial temporal lobe (MTL) respond to novel designs of different usefulness. Taking the "familiar useful" design as a baseline, we found that the right MTL showed increased activation in response to "novel useful" designs, followed by "novel useless" ones, while the left MTL only showed increased activation in response to "novel useful" designs. Calculating an asymmetry index suggests that usefulness processing is predominant in the left MTL, whereas the right MTL is predominantly involved in novelty processing. Moreover, the left parahippocampal gyrus (PHG) showed stronger functional connectivity with the anterior cingulate cortex when responding to "novel useless" designs. In contrast, the right PHG showed stronger connectivity with the amygdala, midbrain, and hippocampus. Critically, multivoxel representational similarity analyses revealed that the left MTL was more effective than the right MTL at distinguishing the usefulness differences in novel stimuli, while representational patterns in the left PHG positively predicted the post-behavior evaluation of "truly creative" products. These findings suggest an apparent dissociation of the left and right MTL in integrating the novelty and usefulness information and novel associative processing during creativity evaluation, respectively. Our results provide novel insights into a longstanding and controversial question in creativity research by demonstrating functional lateralization of the MTL in processing novel associations. |
| 收录类别 | SCI |
| WOS关键词 | ANTERIOR CINGULATE CORTEX ; RIGHT-HEMISPHERE ; EPISODIC MEMORY ; OBJECT REPRESENTATIONS ; PREFRONTAL CORTEX ; NOVELTY DETECTION ; BRAIN NETWORK ; FMRI DATA ; HIPPOCAMPUS ; AMYGDALA |
| 资助项目 | National Natural Science Foundation of China[31871093] ; National Natural Science Foundation of China[32130045] ; National Natural Science Foundation of China[31671124] ; Capacity Building for Sci-Tech Innovation-Fundamental Scientific Research Funds[047-19530050133] ; Capacity Building for Sci-Tech Innovation-Fundamental Scientific Research Funds[025-185305000] ; Boehinger Ingelheim Fonds for Basic Research in Medicine of Germany |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000800666800001 |
| 出版者 | OXFORD UNIV PRESS INC |
| 资助机构 | National Natural Science Foundation of China ; Capacity Building for Sci-Tech Innovation-Fundamental Scientific Research Funds ; Boehinger Ingelheim Fonds for Basic Research in Medicine of Germany |
| 源URL | [http://ir.psych.ac.cn/handle/311026/42721]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Ren, Jingyuan; Luo, Jing |
| 作者单位 | 1.Chinese Inst Brain Res, Beijing 102206, Peoples R China 2.Shaoxing Univ, Dept Psychol, Shaoxing 312000, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 4.Beijing Normal Univ, IDG McGovern Inst Brain Res, Fac Psychol, Beijing 100875, Peoples R China 5.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Fac Psychol, Beijing 100875, Peoples R China 6.Univ Zurich, Ctr Competence Sleep & Hlth Zurich, CH-8091 Zurich, Switzerland 7.Jiangxi Normal Univ, Sch Psychol, Nanchang 330022, Jiangxi, Peoples R China 8.Radboud Univ Nijmegen Med Ctr, Donders Inst Brain Cognit & Behav, Trigon Bldg,Kapittelweg 29, NL-6525 EN Nijmegen, Netherlands 9.Capital Normal Univ, Sch Psychol, Beijing Key Lab Learning & Cognit, Baiduizijia 23, Beijing 100048, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ren, Jingyuan,Huang, Furong,Gao, Chuanji,et al. Functional lateralization of the medial temporal lobe in novel associative processing during creativity evaluation[J]. CEREBRAL CORTEX,2022:21. |
| APA | Ren, Jingyuan.,Huang, Furong.,Gao, Chuanji.,Gott, Jarrod.,Schoch, Sarah F..,...&Luo, Jing.(2022).Functional lateralization of the medial temporal lobe in novel associative processing during creativity evaluation.CEREBRAL CORTEX,21. |
| MLA | Ren, Jingyuan,et al."Functional lateralization of the medial temporal lobe in novel associative processing during creativity evaluation".CEREBRAL CORTEX (2022):21. |
入库方式： OAI收割
来源：心理研究所
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