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Dose Optimization of Anxiolytic Compounds Group in Valeriana jatamansi Jones and Mechanism Exploration by Integrating Network Pharmacology and Metabolomics Analysis

文献类型：期刊论文

作者Zhao, Chengbowen2,3; Wei, Xiaojia3; Guo, Jianyou1; Ding, Yongsheng3; Luo, Jing3; Yang, Xue3; Li, Jiayuan3; Wan, Guohui3; Yu, Jiahe3; Shi, Jinli3
刊名BRAIN SCIENCES
出版日期2022-05-01
卷号12期号:5页码:21
关键词Valeriana jatamansi Jones anxiety disorder network pharmacology metabolomics arachidonic acid metabolism
DOI10.3390/brainsci12050589
通讯作者Shi, Jinli(shijl@bucm.edu.com)
英文摘要Anxiety disorder impacts the quality of life of the patients. The 95% ethanol extract of rhizomes and roots of Valeriana jatamansi Jones (Zhi zhu xiang, ZZX) has previously been shown to be effective for the treatment of anxiety disorder. In this study, the dose ratio of each component of the anxiolytic compounds group (ACG) in a 95% ethanol extract of ZZX was optimized by a uniform design experiment and mathematical modeling. The anxiolytic effect of ACG was verified by behavioral experiments and biochemical index measurement. Network pharmacology was used to determine potential action targets, as well as predict biological processes and signaling pathways, which were then verified by molecular docking analysis. Metabolomics was then used to screen and analyze metabolites in the rat hippocampus before and after the administration of ZZX-ACG. Finally, the results of metabolomics and network pharmacology were integrated to clarify the anti-anxiety mechanism of the ACG. The optimal dose ratio of ACG in 95% ethanol extract of ZZX was obtained, and our results suggest that ACG may regulate ALB, AKT1, PTGS2, CYP3A4, ESR1, CASP3, CYP2B6, EGFR, SRC, MMP9, IGF1, and MAPK8, as well as the prolactin signaling pathway, estrogen signaling pathway, and arachidonic acid metabolism pathway, thus affecting the brain neurotransmitters and HPA axis hormone levels to play an anxiolytic role, directly or indirectly.
收录类别SCI
WOS关键词ANXIETY ; ESTROGEN ; RECEPTOR ; STRESS ; EXPRESSION ; PROLACTIN ; APOPTOSIS ; AMYGDALA ; EXTRACT ; GPR30
资助项目National Natural Science Foundation of China[81673560] ; National Natural Science Foundation of China[82073971]
WOS研究方向Neurosciences & Neurology
语种英语
出版者MDPI
WOS记录号WOS:000803450600001
资助机构National Natural Science Foundation of China
源URL[http://ir.psych.ac.cn/handle/311026/42749]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Shi, Jinli
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100083, Peoples R China
2.Beijing Univ Chinese Med, Dongzhimen Hosp, Beijing 100007, Peoples R China
3.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102488, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Chengbowen,Wei, Xiaojia,Guo, Jianyou,et al. Dose Optimization of Anxiolytic Compounds Group in Valeriana jatamansi Jones and Mechanism Exploration by Integrating Network Pharmacology and Metabolomics Analysis[J]. BRAIN SCIENCES,2022,12(5):21.
APA Zhao, Chengbowen.,Wei, Xiaojia.,Guo, Jianyou.,Ding, Yongsheng.,Luo, Jing.,...&Shi, Jinli.(2022).Dose Optimization of Anxiolytic Compounds Group in Valeriana jatamansi Jones and Mechanism Exploration by Integrating Network Pharmacology and Metabolomics Analysis.BRAIN SCIENCES,12(5),21.
MLA Zhao, Chengbowen,et al."Dose Optimization of Anxiolytic Compounds Group in Valeriana jatamansi Jones and Mechanism Exploration by Integrating Network Pharmacology and Metabolomics Analysis".BRAIN SCIENCES 12.5(2022):21.

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来源：心理研究所

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