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Tardive dyskinesia in Chinese patients with schizophrenia: Prevalence, clinical correlates and relationship with cognitive impairment

文献类型：期刊论文

作者Liang, Qilin4,5; Wang, Dongmei2,3; Zhou, Huixia2,3; Chen, Dachun1; Xiu, Meihong1; Cui, Lixia4,5; Zhang, Xiangyang2,3
刊名JOURNAL OF PSYCHIATRIC RESEARCH
出版日期2022-07-01
卷号151页码:181-187
关键词Schizophrenia Tardive dyskinesia Clinical symptom Cognition
ISSN号0022-3956
DOI10.1016/j.jpsychires.2022.04.029
通讯作者Cui, Lixia(clx668@163.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Objective: Tardive dyskinesia (TD) has a high prevalence and is one of the distressing side effects of antipsychotic medications. Few studies have explored the relationship between TD, clinical correlates, and cognition. The aim of this study was to assess the prevalence, clinical correlates and cognitive impairment of co-occurring TD in Chinese patients with schizophrenia. Methods: We recruited 655 patients with chronic schizophrenia who met the DSM-IV diagnostic criteria for schizophrenia and collected clinical and demographic data. All patients were assessed using the Abnormal Involuntary Movement Scale (AIMS) for the severity of TD, Positive and Negative Syndrome Scale (PANSS) for psychopathological symptoms, and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) for cognition. Results: The overall TD prevalence was 41.1%, 42.9% (246/574) in men and 28.4% (23/81) in women (chi 2 = 6.1 df = 1, p < 0.05). There were significant differences in age, sex, duration of illness, number of hospitalizations, drug type, smoking and PANSS negative symptom subscore between TD and non-TD groups (all p < 0.05). Moreover, patients with TD scored lower for immediate memory, attention, delayed memory, and RBANS total scores (all p < 0.05). Logistic regression showed a significant correlation between TD and age, sex, drug type and attention subscore. Conclusion: Our results suggest that multiple demographic and clinical variables may be associated with the development of TD. Moreover, TD patients may exhibit more cognitive impairment than non-TD patients.
收录类别SCI
WOS关键词PSYCHIATRIC-PATIENTS ; GENDER-DIFFERENCES ; NEGATIVE SYMPTOMS ; ANTIPSYCHOTICS ; ASSOCIATION ; RISK ; CLOZAPINE ; DYSFUNCTION ; CYP2D6 ; POLYMORPHISMS
资助项目Beijing Philosophy and Social Science Planning Program and Social Science Research Key Program of Beijing Municipal Commission of Education[SZ202210028012] ; CAS International Cooperation Research Program[153111KYSB20190004]
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:000797532400025
出版者PERGAMON-ELSEVIER SCIENCE LTD
资助机构Beijing Philosophy and Social Science Planning Program and Social Science Research Key Program of Beijing Municipal Commission of Education ; CAS International Cooperation Research Program
源URL[http://ir.psych.ac.cn/handle/311026/42752]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Cui, Lixia; Zhang, Xiangyang
作者单位1.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
4.Capital Normal Univ, Sch Psychol, Beijing 100037, Peoples R China
5.Capital Normal Univ, Sch Psychol, Beijing Key Lab Learning, Beijing 100037, Peoples R China
推荐引用方式
GB/T 7714		 Liang, Qilin,Wang, Dongmei,Zhou, Huixia,et al. Tardive dyskinesia in Chinese patients with schizophrenia: Prevalence, clinical correlates and relationship with cognitive impairment[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2022,151:181-187.
APA Liang, Qilin.,Wang, Dongmei.,Zhou, Huixia.,Chen, Dachun.,Xiu, Meihong.,...&Zhang, Xiangyang.(2022).Tardive dyskinesia in Chinese patients with schizophrenia: Prevalence, clinical correlates and relationship with cognitive impairment.JOURNAL OF PSYCHIATRIC RESEARCH,151,181-187.
MLA Liang, Qilin,et al."Tardive dyskinesia in Chinese patients with schizophrenia: Prevalence, clinical correlates and relationship with cognitive impairment".JOURNAL OF PSYCHIATRIC RESEARCH 151(2022):181-187.

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来源：心理研究所

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