Interaction between the BDNF gene rs16917237 polymorphism and job stress on job burnout of Chinese university teachers
文献类型：期刊论文
| 作者 | Li, Yuling11; Xue, Tao9,10; Jin, Jeff9; Wu, Hanjing Emily9; Dong, Yan4,8; Zhen, Shiqian3,7; He, Shu-Chang2,11; Zhang, Xiang Yang1,6
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| 刊名 | JOURNAL OF AFFECTIVE DISORDERS
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| 出版日期 | 2022-07-15 |
| 卷号 | 309页码:282-288 |
| ISSN号 | 0165-0327 |
| 关键词 | Job burnout Job stress BDNF (brain-derived neurotrophic factor gene) rs16917237 Gene-by-environment interaction |
| DOI | 10.1016/j.jad.2022.04.135 |
| 通讯作者 | Dong, Yan(dong8958@126.com) ; Zhen, Shiqian(shiqianzh@163.com) ; He, Shu-Chang(shuchangh@pku.edu.cn) ; Zhang, Xiang Yang(zhangxy@psych.ac.cn) |
| 英文摘要 | Background: Job burnout is related to both environmental and genetic factors. However, previous studies on job burnout in teachers have mainly focused on potential stressors in the environment, while ignoring genetic factors. Brain-derived neurotrophic factor (BNDF) may be a pathogenic factor involved in burnout symptoms. Therefore, this study further investigated the relationship between the BNDF gene polymorphism, job stress and job burnout in Chinese university teachers. Methods: Using a cross-sectional design, 361 faculty and staff members from a university in Beijing were enrolled. Job stress was measured with the Work Stress Scale. Job burnout was measured by the Chinese version of the Maslach Burnout Inventory which has three dimensions, namely emotional exhaustion (EE), cynicism (CY), and reduced personal accomplishment (PA). The BDNF gene rs16917237 polymorphism was genotyped in all participants. Results: CY score was associated with education level (p < 0.01), and PA score was associated with age (p < 0.05). Job stress was positively correlated with EE (r = 0.776), CY (r = 0.457), and PA (r = 0.163) (all p < 0.01). After controlling for gender, age and education level, the BDNF gene rs16917237 polymorphism did not affect job burnout, but it interacted with job stress to influence EE and CY (both p < 0.05), indicating that individuals with TT genotype were more susceptible to higher levels of job stress, resulting in job burnout symptoms. Conclusions: Our results suggest that the BDNF gene rs16917237 TT genotype may be a risk factor for job burnout in Chinese university teachers. |
| 收录类别 | SCI |
| WOS关键词 | NEUROTROPHIC FACTOR LEVELS ; SERUM BDNF ; ASSOCIATION ; DIMENSIONS ; APPRAISALS ; EFFICACY |
| WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000799879700001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/42781]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Dong, Yan; Zhen, Shiqian; He, Shu-Chang; Zhang, Xiang Yang |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Peking Univ, 5 Yiheyuan Rd, Beijing 100871, Peoples R China 3.Chinese Acad Int Trade & Econ Cooperat, 28 Donghou lane, Andingmenwai, Beijing 100710, Peoples R China 4.Renmin Univ China, 59 Zhongguancun Ave, Beijing 100871, Peoples R China 5.Qingdao Cent Hosp, Affiliated Qingdao Cent Hosp, Dept Plast Surg, Qingdao, Peoples R China 6.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 7.Chinese Acad Int Trade & Econ Cooperat, Inst Circulat & Consumpt, Beijing 100710, Peoples R China 8.Renmin Univ China, Dept Psychol, Beijing 100871, Peoples R China 9.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX USA 10.Qingdao Univ, Qingdao Cent Hosp, Affiliated Qingdao Cent Hosp, Dept Burn, Qingdao 266042, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yuling,Xue, Tao,Jin, Jeff,et al. Interaction between the BDNF gene rs16917237 polymorphism and job stress on job burnout of Chinese university teachers[J]. JOURNAL OF AFFECTIVE DISORDERS,2022,309:282-288. |
| APA | Li, Yuling.,Xue, Tao.,Jin, Jeff.,Wu, Hanjing Emily.,Dong, Yan.,...&Zhang, Xiang Yang.(2022).Interaction between the BDNF gene rs16917237 polymorphism and job stress on job burnout of Chinese university teachers.JOURNAL OF AFFECTIVE DISORDERS,309,282-288. |
| MLA | Li, Yuling,et al."Interaction between the BDNF gene rs16917237 polymorphism and job stress on job burnout of Chinese university teachers".JOURNAL OF AFFECTIVE DISORDERS 309(2022):282-288. |
入库方式： OAI收割
来源：心理研究所
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