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Genotype-genotype interactions of the OXTR gene polymorphisms are associated with self-reported daytime dysfunction, sleep latency and personal distress

文献类型：期刊论文

作者Li, Yuling5,6; Wang, Yuan4; Guan, Xin4; Yue, Jingyan3; Wu, Hanjing Emily3; Zhen, Shiqian2; He, Shu-Chang5,6; Zhang, Xiang-Yang1
刊名JOURNAL OF SLEEP RESEARCH
出版日期2022-06-15
页码12
ISSN号0962-1105
关键词daytime dysfunction emotional empathy genotype-genotype interaction oxytocin receptor gene (OXTR) personal distress sleep latency
DOI10.1111/jsr.13668
通讯作者Zhen, Shiqian(zhenshiqian@caitec.org.cn) ; He, Shu-Chang(shuchangh@pku.edu.cn) ; Zhang, Xiang-Yang(zhangxy@psych.ac.cn)
英文摘要The oxytocin receptors located in the corticotropin-releasing factor neurons of the paraventricular nucleus are stimulated by oxytocin. Oxytocin functions as the regulator of the corticotropin-releasing factor system and in turn promotes sleep quality. The objective of this study was to examine the main and genotype-genotype interactive effects of the oxytocin receptor gene (OXTR) polymorphisms on sleep quality. A total of 324 participants were randomly recruited from a university in Beijing, China. Sleep quality was measured with the Pittsburgh Sleep Quality Index. The OXTR single-nucleotide polymorphisms (rs2254298, rs2268498, rs13316193, rs2268490 and rs2268491) were genotyped. The results showed that gender and age were associated with various empathy traits (all p < 0.001). The Pittsburgh Sleep Quality Index was positively correlated with the Personal Distress subscale of empathy (p < 0.001). Both rs2254298 and rs2268491 interacted with rs13316193 to influence daytime dysfunction and Personal Distress (all p < 0.05), indicating that in individuals with rs13316193 CC/CT genotype, those with rs2254298 AA/AG or rs2268491 TT/TC genotypes displayed higher daytime dysfunction and Personal Distress scores than those with rs2254298 GG or rs2268491 CC genotypes. Conversely, among the individuals with rs2254298 GG or rs2268491 CC genotypes, the rs13316193 C allele carriers had lower daytime dysfunction and Personal Distress scores than rs13316193 TT homozygotes. There was also a significant interaction between rs2268490 and rs2268498 on the sleep latency dimension of the Pittsburgh Sleep Quality Index. Our findings reveal for the first time the genotype-genotype interactions of the OXTR gene on sleep quality, which may open new research avenues for studying psychopathology involving sleep problems.
收录类别SCI
WOS关键词OXYTOCIN NEURONS ; WAKE BEHAVIOR ; RECEPTOR ; SYSTEM ; EMPATHY ; IMPACT ; DEPRIVATION ; WAKEFULNESS ; POPULATION ; QUALITY
资助项目National Natural Science Foundation of China[81871060]
WOS研究方向Neurosciences & Neurology
语种英语
出版者WILEY
WOS记录号WOS:000811358100001
资助机构National Natural Science Foundation of China
源URL[http://ir.psych.ac.cn/handle/311026/42785]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhen, Shiqian; He, Shu-Chang; Zhang, Xiang-Yang
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Chinese Acad Int Trade & Econ Cooperat, Inst Circulat & Consumpt, 28 Donghou Lane, Beijing 100710, Peoples R China
3.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
4.PLA Strateg Support Force Med Ctr, Beijing, Peoples R China
5.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Beijing, Peoples R China
6.Peking Univ, Sch Psychol & Cognit Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Li, Yuling,Wang, Yuan,Guan, Xin,et al. Genotype-genotype interactions of the OXTR gene polymorphisms are associated with self-reported daytime dysfunction, sleep latency and personal distress[J]. JOURNAL OF SLEEP RESEARCH,2022:12.
APA Li, Yuling.,Wang, Yuan.,Guan, Xin.,Yue, Jingyan.,Wu, Hanjing Emily.,...&Zhang, Xiang-Yang.(2022).Genotype-genotype interactions of the OXTR gene polymorphisms are associated with self-reported daytime dysfunction, sleep latency and personal distress.JOURNAL OF SLEEP RESEARCH,12.
MLA Li, Yuling,et al."Genotype-genotype interactions of the OXTR gene polymorphisms are associated with self-reported daytime dysfunction, sleep latency and personal distress".JOURNAL OF SLEEP RESEARCH (2022):12.

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来源：心理研究所

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