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Association of serum lipid levels with psychotic symptoms in first-episode and drug naive outpatients with major depressive disorder: a large-scale cross-sectional study

文献类型：期刊论文

作者Wang, Xiaohong6; Yang, Liying6; Liu, Jiacheng6; Kang, Chuanyi6; Zheng, Yue6; Qiu, Siyu5; Zhao, Ying4; Goodman, Colin B.3; Wu, Hanjing Emily3; Zhao, Na6
刊名JOURNAL OF AFFECTIVE DISORDERS
出版日期2022-01-15
卷号297页码:321-326
关键词Psychotic symptoms Major depressive disorder TG TC LDL-C
ISSN号0165-0327
DOI10.1016/j.jad.2021.10.053
通讯作者Zhao, Na(zn8296@163.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Background Major depressive disorder (MDD) is a prevalent psychiatric disorder, with increasing evidence that patients with MDD display psychotic symptoms. Studies have shown the association between lipid levels and MDD, but few have explored the relationship between lipids and psychotic symptoms in MDD. The objective of this study was to compare the differences of lipid levels between patients with psychotic major depressive disorder (PMD) and those with non-psychotic major depressive disorder (NPMD) in first-episode and drug-naive (FEDN) MDD patients. Methods A total of 1718 outpatients with FEDN MDD were recruited. In addition to collecting basic information, their blood specimens were also collected to detect serum TC, HDL-C, TG, and LDL-C. The Hamilton depression scale (HAMD), Hamilton anxiety scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) were used to assess their depression, anxiety, and psychotic symptoms respectively. Results Compared to those with NPMD, those with PMD had higher scores on HAMD, HAMA, and more elevated serum TC, TG, and LDL-C levels, but lower HDL-C levels (all p < 0.05). Further logistic regression analysis showed that TG, the severity of depressive and anxiety symptoms were significantly associated with psychotic symptoms (p < 0.05). Limitations No causal relationship could be drawn due to the cross-sectional design. Conclusions Psychotic symptoms in patients with MDD may be predicted by lipid levels in the future. Our findings suggest that TG seems to predict the presence of current psychotic features among patients with FEDN MDD.
收录类别SCI
WOS关键词UNIPOLAR DEPRESSION ; TRIGLYCERIDE LEVELS ; NIACIN RESPONSE ; SCHIZOPHRENIA ; ENDOPHENOTYPE ; CHOLESTEROL ; SPECIFICITY ; MARKERS ; HDL
资助项目First Affiliated Hospital of Harbin Medical University[2020B07]
WOS研究方向Neurosciences & Neurology ; Psychiatry
语种英语
WOS记录号WOS:000808544900017
出版者ELSEVIER
资助机构First Affiliated Hospital of Harbin Medical University
源URL[http://ir.psych.ac.cn/handle/311026/42810]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhao, Na; Zhang, Xiangyang
作者单位1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
4.Harbin Med Univ, Dept Lab, Affiliated Hosp 4, Harbin, Heilongjiang, Peoples R China
5.Harbin Med Univ, Dept Gastroenterol, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
6.Harbin Med Univ, Dept Psychiat, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Xiaohong,Yang, Liying,Liu, Jiacheng,et al. Association of serum lipid levels with psychotic symptoms in first-episode and drug naive outpatients with major depressive disorder: a large-scale cross-sectional study[J]. JOURNAL OF AFFECTIVE DISORDERS,2022,297:321-326.
APA Wang, Xiaohong.,Yang, Liying.,Liu, Jiacheng.,Kang, Chuanyi.,Zheng, Yue.,...&Zhang, Xiangyang.(2022).Association of serum lipid levels with psychotic symptoms in first-episode and drug naive outpatients with major depressive disorder: a large-scale cross-sectional study.JOURNAL OF AFFECTIVE DISORDERS,297,321-326.
MLA Wang, Xiaohong,et al."Association of serum lipid levels with psychotic symptoms in first-episode and drug naive outpatients with major depressive disorder: a large-scale cross-sectional study".JOURNAL OF AFFECTIVE DISORDERS 297(2022):321-326.

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来源：心理研究所

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