中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 心理研究所
  3. 中国科学院心理研究所
  4. 中国科学院心理健康重点实验室
Association Between Depressive Symptoms and Serum Brain-Derived Neurotrophic Factor Levels in Patients With First-Episode and Drug-Naive Schizophrenia

文献类型：期刊论文

作者Wu, Yuxuan4,5; Du, Xiangdong4; Yang, Ruchang4,5; Yue, Yan4,5; Peng, Ruijie4,5; Wu, Siqi3; Wang, Haitao3; Zhou, Yue2,4; Fang, Xiaojia2,4; Yuan, Nian4
刊名FRONTIERS IN PSYCHIATRY
出版日期2022-06-09
卷号13页码:8
ISSN号1664-0640
关键词schizophrenia depressive symptoms brain-derived neurotrophic factor first episode psychosis serum
DOI10.3389/fpsyt.2022.911384
通讯作者Du, Xiangdong(xiangdong-du@163.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Previous studies have revealed that brain-derived neurotrophic factor (BDNF) levels are inversely associated with the severity of depressive symptoms. In addition, serum BDNF levels tend to increase with improvement in depressive symptoms. There is also evidence that BDNF has a possible role in the pathophysiology of schizophrenia. Therefore, the purpose of this study was to determine whether BDNF levels correlated with depressive symptoms in patients with first-episode and drug-naive (FEDN) schizophrenia. In this study, 90 patients with FEDN schizophrenia and 60 healthy controls were recruited. The Positive and Negative Syndrome Scale (PANSS) and the 17-item Hamilton Depression Scale (HAMD-17) were used to gage psychopathological and depressive symptoms, respectively. All participants had their BDNF levels measured using a sandwich enzyme-linked immunosorbent test. Serum BDNF levels were lower in patients with FEDN schizophrenia compared with healthy controls. Moreover, patients with depressive symptoms exhibited a higher PANSS total score and a higher general psychopathology score than those without depressive symptoms (p < 0.05). For patients with depressive symptoms, serum BDNF levels were higher than in those without depressive symptoms (p < 0.05). An association between BDNF levels and the positive subscore was also observed (p < 0.01). However, there was no significant association between BDNF levels and HAMD scores (p > 0.05). In conclusion, BDNF levels were shown to be higher in the serum of patients with FEDN schizophrenia with depressive symptoms than in those without. Additionally, low levels of serum BDNF may contribute to the positive symptoms of FEDN schizophrenia but not to depressive symptoms.
收录类别SCI
WOS关键词BDNF LEVELS ; NEGATIVE SYMPTOMS ; OXIDATIVE STRESS ; 1ST EPISODE ; MOOD DISORDERS ; DOPAMINE ; POLYMORPHISM ; PREVALENCE ; HYPOTHESIS ; BIOMARKERS
WOS研究方向Psychiatry
语种英语
出版者FRONTIERS MEDIA SA
WOS记录号WOS:000814881500001
源URL[http://ir.psych.ac.cn/handle/311026/42847]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Du, Xiangdong; Zhang, Xiangyang
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Xuzhou Med Univ, Xuzhou, Peoples R China
3.North China Univ Sci & Technol, Sch Psychol & Mental Hlth, Tangshan, Peoples R China
4.Affiliated Guangji Hosp Soochow Univ, Suzhou Guangji Hosp, Suzhou, Peoples R China
5.Suzhou Med Coll Soochow Univ, Suzhou, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Yuxuan,Du, Xiangdong,Yang, Ruchang,et al. Association Between Depressive Symptoms and Serum Brain-Derived Neurotrophic Factor Levels in Patients With First-Episode and Drug-Naive Schizophrenia[J]. FRONTIERS IN PSYCHIATRY,2022,13:8.
APA Wu, Yuxuan.,Du, Xiangdong.,Yang, Ruchang.,Yue, Yan.,Peng, Ruijie.,...&Zhang, Xiangyang.(2022).Association Between Depressive Symptoms and Serum Brain-Derived Neurotrophic Factor Levels in Patients With First-Episode and Drug-Naive Schizophrenia.FRONTIERS IN PSYCHIATRY,13,8.
MLA Wu, Yuxuan,et al."Association Between Depressive Symptoms and Serum Brain-Derived Neurotrophic Factor Levels in Patients With First-Episode and Drug-Naive Schizophrenia".FRONTIERS IN PSYCHIATRY 13(2022):8.

入库方式： OAI收割

来源：心理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。