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Pain-related reorganization in the primary somatosensory cortex of patients with postherpetic neuralgia

文献类型：期刊论文

作者Li, Hong4,5; Li, Xiaoyun3,4; Wang, Jiyuan4,5; Gao, Fei2; Wiech, Katja; Hu, Li3,4; Kong, Yazhuo1,4,5
刊名HUMAN BRAIN MAPPING
出版日期2022-06-25
页码13
ISSN号1065-9471
关键词functional magnetic resonance imaging pain perception postherpetic neuralgia primary somatosensory cortex (S1) reorganization
DOI10.1002/hbm.25992
通讯作者Hu, Li(huli@psych.ac.cn) ; Kong, Yazhuo(kongyz@psych.ac.cn)
英文摘要Studies on functional and structural changes in the primary somatosensory cortex (S1) have provided important insights into neural mechanisms underlying several chronic pain conditions. However, the role of S1 plasticity in postherpetic neuralgia (PHN) remains elusive. Combining psychophysics and magnetic resonance imaging (MRI), we investigated whether pain in PHN patients is linked to S1 reorganization as compared with healthy controls. Results from voxel-based morphometry showed no structural differences between groups. To characterize functional plasticity, we compared S1 responses to noxious laser stimuli of a fixed intensity between both groups and assessed the relationship between S1 activation and spontaneous pain in PHN patients. Although the intensity of evoked pain was comparable in both groups, PHN patients exhibited greater activation in S1 ipsilateral to the stimulated hand. Pain-related activity was identified in contralateral superior S1 (SS1) in controls as expected, but in bilateral inferior S1 (IS1) in PHN patients with no overlap between SS1 and IS1. Contralateral SS1 engaged during evoked pain in controls encoded spontaneous pain in patients, suggesting functional S1 reorganization in PHN. Resting-state fMRI data showed decreased functional connectivity between left and right SS1 in PHN patients, which scaled with the intensity of spontaneous pain. Finally, multivariate pattern analyses (MVPA) demonstrated that BOLD activity and resting-state functional connectivity of S1 predicted within-subject variations of evoked and spontaneous pain intensities across groups. In summary, functional reorganization in S1 might play a key role in chronic pain related to PHN and could be a potential treatment target in this patient group.
收录类别SCI
WOS关键词CORTICAL REORGANIZATION ; NEUROPATHIC PAIN ; FUNCTIONAL MRI ; BRAIN ACTIVITY ; MEDIAN NERVE ; MECHANISMS ; PERCEPTION ; RESPONSES ; ACCURATE ; ATROPHY
资助项目National Natural Science Foundation of China[81871436] ; National Natural Science Foundation of China[31671141] ; National Natural Science Foundation of China[31822025] ; National Natural Science Foundation of China[82072010] ; National Natural Science Foundation of China[82101610]
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
语种英语
出版者WILEY
WOS记录号WOS:000815587600001
资助机构National Natural Science Foundation of China
源URL[http://ir.psych.ac.cn/handle/311026/42860]  
专题心理研究所_中国科学院心理健康重点实验室
心理研究所_中国科学院行为科学重点实验室
通讯作者Hu, Li; Kong, Yazhuo
作者单位1.Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Wellcome Ctr Integrat Neuroimaging WIN, Oxford, England
2.Peking Univ Peoples Hosp, Dept Pain Med, Beijing, Peoples R China
3.CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.CAS Key Lab Behav Sci, Inst Psychol, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Li, Hong,Li, Xiaoyun,Wang, Jiyuan,et al. Pain-related reorganization in the primary somatosensory cortex of patients with postherpetic neuralgia[J]. HUMAN BRAIN MAPPING,2022:13.
APA Li, Hong.,Li, Xiaoyun.,Wang, Jiyuan.,Gao, Fei.,Wiech, Katja.,...&Kong, Yazhuo.(2022).Pain-related reorganization in the primary somatosensory cortex of patients with postherpetic neuralgia.HUMAN BRAIN MAPPING,13.
MLA Li, Hong,et al."Pain-related reorganization in the primary somatosensory cortex of patients with postherpetic neuralgia".HUMAN BRAIN MAPPING (2022):13.

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来源：心理研究所

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