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Altered Dynamic Functional Connectivity in Early Psychosis Between the Salience Network and Visual Network

文献类型：期刊论文

作者Zhao, Lei4,5,6,7; Bo, Qijing4,5,6,7; Zhang, Zhifang4,5,6,7; Chen, Zhenzhu4,5,6,7; Wang, Yimeng4,5,6,7; Zhang, Douyu4,5,6,7; Li, Tian4,5,6,7; Yang, Ningbo1; Zhou, Yuan2,3,5,6,7; Wang, Chuanyue4,5,6,7
刊名NEUROSCIENCE
出版日期2022-05-21
卷号491页码:166-175
ISSN号0306-4522
关键词first-episode schizophrenia clinical high risk for psychosis salience network visual network default mode network dynamic functional connectivity
DOI10.1016/j.neuroscience.2022.04.002
通讯作者Zhou, Yuan(zhouyuan@psych.ac.cn) ; Wang, Chuanyue(wcyadyy@163.com)
英文摘要early psychosis there are alterations in the static functional interaction between the salience network (SN) and higher-order cognitive networks. It is unclear whether these changes extend to the dynamic functional connectivity (dFC) of the SN, and whether the dFC between the SN and low-order networks (e.g., sensory networks) is affected. This study examined the temporal properties of the functional connectivity of the SN in individuals with early psychosis. In this study, selected core regions of the SN included the left and right anterior insula (AIs) and anterior cingulate cortex (ACC), based on independent component analysis of 26 and 20 subjects with first-episode schizophrenia (FES) or at clinical high risk for psychosis (CHR), and 37 healthy controls (HC). The dFC of each region was investigated via sliding window-based analyses with whole brain voxels. We found compared with the HC, in the FES and CHR groups the bilateral AI and ACC showed less variability in dFC with regions in the visual network; the variability between the ACC and visual regions in the FES group was less than that of the CHR; and in the FES and CHR groups the variability in dFC was higher between the right AI and the left precuneus (a core region of the default mode network). This study confirmed abnormality of dynamic functional interaction between the SN and the DMN in psychosis. More importantly, the disruption of communication between the SN and the lower-order brain network is another important aspect of the neural basis of psychosis. (c) 2022 IBRO. Published by Elsevier Ltd. All rights reserved.
收录类别SCI
WOS关键词AUDITORY VERBAL HALLUCINATIONS ; RESTING-STATE CONNECTIVITY ; 1ST EPISODE PSYCHOSIS ; BRAIN NETWORKS ; SCHIZOPHRENIA ; PRECUNEUS ; CORTEX ; INDIVIDUALS ; MODULATION ; RESPONSES
资助项目National Science and Technology Major Project for IND (investigational new drug)[2018ZX09201-014] ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support[ZYLX201807] ; Beijing Municipal Natural Science Foundation[7192081] ; National Natural Science Foundation of China[81901355]
WOS研究方向Neurosciences & Neurology
语种英语
出版者PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号WOS:000793823600002
资助机构National Science and Technology Major Project for IND (investigational new drug) ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support ; Beijing Municipal Natural Science Foundation ; National Natural Science Foundation of China
源URL[http://ir.psych.ac.cn/handle/311026/42678]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Zhou, Yuan; Wang, Chuanyue
作者单位1.Henan Univ Sci & Technol, Affiliated Hosp 1, Dept Psychiat, Luoyang 471003, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
3.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
4.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing 100069, Peoples R China
5.Capital Med Univ, Beijing Anding Hosp, Beijing Inst Brain Disorders Ctr Schizophrenia, Beijing 100088, Peoples R China
6.Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing 100088, Peoples R China
7.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing 100088, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Lei,Bo, Qijing,Zhang, Zhifang,et al. Altered Dynamic Functional Connectivity in Early Psychosis Between the Salience Network and Visual Network[J]. NEUROSCIENCE,2022,491:166-175.
APA Zhao, Lei.,Bo, Qijing.,Zhang, Zhifang.,Chen, Zhenzhu.,Wang, Yimeng.,...&Wang, Chuanyue.(2022).Altered Dynamic Functional Connectivity in Early Psychosis Between the Salience Network and Visual Network.NEUROSCIENCE,491,166-175.
MLA Zhao, Lei,et al."Altered Dynamic Functional Connectivity in Early Psychosis Between the Salience Network and Visual Network".NEUROSCIENCE 491(2022):166-175.

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来源：心理研究所

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