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Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder

文献类型：期刊论文

作者Ding, Yu-Dan42,43; Chen, Xiao39,40,41; Chen, Zuo-Bing38; Li, Le37; Li, Xue-Ying35,36,41; Castellanos, Francisco Xavier33,34; Bai, Tong-Jian32; Bo, Qi-Jing31; Cao, Jun30; Chang, Zhi-Kai40,41
刊名TRANSLATIONAL PSYCHIATRY
出版日期2022-06-06
卷号12期号:1页码:9
ISSN号2158-3188
DOI10.1038/s41398-022-01995-x
通讯作者Ding, Yu-Dan()
英文摘要The nucleus accumbens (NAc) is considered a hub of reward processing and a growing body of evidence has suggested its crucial role in the pathophysiology of major depressive disorder (MDD). However, inconsistent results have been reported by studies on reward network-focused resting-state functional MRI (rs-fMRI). In this study, we examined functional alterations of the NAc-based reward circuits in patients with MDD via meta- and mega-analysis. First, we performed a coordinated-based meta-analysis with a new SDM-PSI method for all up-to-date rs-fMRI studies that focused on the reward circuits of patients with MDD. Then, we tested the meta-analysis results in the REST-meta-MDD database which provided anonymous rs-fMRI data from 186 recurrent MDDs and 465 healthy controls. Decreased functional connectivity (FC) within the reward system in patients with recurrent MDD was the most robust finding in this study. We also found disrupted NAc FCs in the DMN in patients with recurrent MDD compared with healthy controls. Specifically, the combination of disrupted NAc FCs within the reward network could discriminate patients with recurrent MDD from healthy controls with an optimal accuracy of 74.7%. This study confirmed the critical role of decreased FC in the reward network in the neuropathology of MDD. Disrupted inter-network connectivity between the reward network and DMN may also have contributed to the neural mechanisms of MDD. These abnormalities have potential to serve as brain-based biomarkers for individual diagnosis to differentiate patients with recurrent MDD from healthy controls.
收录类别SCI
WOS关键词STRIATAL ACTIVATION ; COGNITIVE CONTROL ; DISRUPTED REWARD ; VISUAL-CORTEX ; ANHEDONIA ; ASSOCIATION ; PREDICTION ; CIRCUITRY ; DEFICITS ; NEURONS
资助项目National Natural Science Foundation of China[82171508] ; Natural Science Foundation of Hunan[2020JJ4784] ; Science and Technology Program of Hunan Province[2020SK53413] ; Key-Area Research and Development Program of Guangdong Province[2018B030334001]
WOS研究方向Psychiatry
语种英语
出版者SPRINGERNATURE
WOS记录号WOS:000806782600004
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Hunan ; Science and Technology Program of Hunan Province ; Key-Area Research and Development Program of Guangdong Province
源URL[http://ir.psych.ac.cn/handle/311026/42775]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Ding, Yu-Dan
作者单位1.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing, Peoples R China
2.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing, Peoples R China
3.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China
4.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Lab Psychol Hlth & Imaging, Sch Med, Shanghai, Peoples R China
5.Shanxi Med Univ, Hosp 1, Taiyuan, Shanxi, Peoples R China
6.Xi An Jiao Tong Univ, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China
7.Zhejiang Key Lab Res Assessment Cognit Impairment, Hangzhou, Zhejiang, Peoples R China
8.Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Inst Psychol Sci, Hangzhou, Zhejiang, Peoples R China
9.Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China
10.Chongqing Key Lab Neurobiol, Chongqing, Peoples R China
推荐引用方式
GB/T 7714		 Ding, Yu-Dan,Chen, Xiao,Chen, Zuo-Bing,et al. Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder[J]. TRANSLATIONAL PSYCHIATRY,2022,12(1):9.
APA Ding, Yu-Dan.,Chen, Xiao.,Chen, Zuo-Bing.,Li, Le.,Li, Xue-Ying.,...&Guo, Wen-Bin.(2022).Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder.TRANSLATIONAL PSYCHIATRY,12(1),9.
MLA Ding, Yu-Dan,et al."Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder".TRANSLATIONAL PSYCHIATRY 12.1(2022):9.

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来源：心理研究所

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