Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities
文献类型：期刊论文
| 作者 | Luo, Han3; Qin, Wei3; Zhang, Hong3; Ren, Fu-Cai1,2; Fang, Wen-Tao3; Kong, Qing-Hua2; Yang, Liu2; Zhang, Jian-Mei2; Fang, Cheng-Wu3; Hu, Jiang-Miao2
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| 刊名 | MOLECULES
 |
| 出版日期 | 2022-03-01 |
| 卷号 | 27期号:5页码:12 |
| 关键词 | Rubia cordifolia anthraquinones NO inhibitory activity antibacterial |
| DOI | 10.3390/molecules27051730 |
| 通讯作者 | Hu, Jiang-Miao(hujiangmiao@mail.kib.ac.cn) ; Liu, Shou-Jin(shjinliu@sina.com) |
| 英文摘要 | The present study aimed to identify the composition of the aerial parts of Rubia cordifolia L. A chemical investigation on the EtOAc extracts from the aerial parts of Rubia cordifolia resulted in the isolation of four new anthraquinones, namely Cordifoquinone A-D (1-4), along with 16 known anthraquinones. Their structures were elucidated on the basis of NMR and HR-ESIMS data. All isolates were assessed for their inhibitory effects on NO production in LPS-stimulated RAW264.7 macrophage cells. Compounds 1, 3 and 10 exhibited significant inhibitory activities with IC50 values of 14.05, 23.48 and 29.23 mu mol.L-1, respectively. Their antibacterial activities of four bacteria, Escherichia coli (ATCC 25922), Staphylococcus aureus subsp. aureus (ATCC 29213), Salmonella enterica subsp. enterica (ATCC 14028) and Pseudomonas aeruginosa (ATCC 27853), were also evaluated. Our results indicated that the antibacterial activity of these compounds is inactive. |
| 语种 | 英语 |
| WOS记录号 | WOS:000814406700001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73839]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Hu, Jiang-Miao; Liu, Shou-Jin |
| 作者单位 | 1.Anhui Med Univ, Coll Pharm, Hefei 230011, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Anhui Univ Chinese Med, Coll Pharm, Hefei 230011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Han,Qin, Wei,Zhang, Hong,et al. Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities[J]. MOLECULES,2022,27(5):12. |
| APA | Luo, Han.,Qin, Wei.,Zhang, Hong.,Ren, Fu-Cai.,Fang, Wen-Tao.,...&Liu, Shou-Jin.(2022).Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities.MOLECULES,27(5),12. |
| MLA | Luo, Han,et al."Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities".MOLECULES 27.5(2022):12. |
入库方式： OAI收割
来源：昆明植物研究所
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