Molluskan Dorsal-Ventral Patterning Relying on BMP2/4 and Chordin Provides Insights into Spiralian Development and Evolution
文献类型：期刊论文
| 作者 | Tan, Sujian1,2,3; Huan, Pin1,2,3; Liu, Baozhong1,2,3
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| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2022-01-07 |
| 卷号 | 39期号:1页码:18 |
| ISSN号 | 0737-4038 |
| 关键词 | dorsal-ventral mollusk organizer BMP Chordin |
| DOI | 10.1093/molbev/msab322 |
| 通讯作者 | Liu, Baozhong(bzliu@qdio.ac.cn) |
| 英文摘要 | Although a conserved mechanism relying on BMP2/4 and Chordin is suggested for animal dorsal-ventral (DV) patterning, this mechanism has not been reported in spiralians, one of the three major clades of bilaterians. Studies on limited spiralian representatives have suggested markedly diverse DV patterning mechanisms, a considerable number of which no longer deploy BMP signaling. Here, we showed that BMP2/4 and Chordin regulate DV patterning in the mollusk Lottia goshimai, which was predicted in spiralians but not previously reported. In the context of the diverse reports in spiralians, it conversely represents a relatively unusual case. We showed that BMP2/4 and Chordin coordinate to mediate signaling from the D-quadrant organizer to induce the DV axis, and Chordin relays the symmetry-breaking information from the organizer. Further investigations on L. goshimai embryos with impaired DV patterning suggested roles of BMP signaling in regulating the behavior of the blastopore and the organization of the nervous system. These findings provide insights into the evolution of animal DV patterning and the unique development mode of spiralians driven by the D-quadrant organizer. |
| 资助项目 | National Key R&D Program of China[2018YFD0900104] ; Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao)[2018SDKJ0302-1] ; China Agriculture Research System[CARS-49] ; National Natural Science Foundation of China[42076123] ; National Natural Science Foundation of China[31472265] ; National Natural Science Foundation of China[41776157] ; Youth Innovation Promotion Association CAS[2018239] ; Taishan Scholar Project Fund of Shandong Province of China[tsqn202103129] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity |
| 语种 | 英语 |
| 出版者 | OXFORD UNIV PRESS |
| WOS记录号 | WOS:000771141500016 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/178651]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Liu, Baozhong |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Peoples R China 3.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tan, Sujian,Huan, Pin,Liu, Baozhong. Molluskan Dorsal-Ventral Patterning Relying on BMP2/4 and Chordin Provides Insights into Spiralian Development and Evolution[J]. MOLECULAR BIOLOGY AND EVOLUTION,2022,39(1):18. |
| APA | Tan, Sujian,Huan, Pin,&Liu, Baozhong.(2022).Molluskan Dorsal-Ventral Patterning Relying on BMP2/4 and Chordin Provides Insights into Spiralian Development and Evolution.MOLECULAR BIOLOGY AND EVOLUTION,39(1),18. |
| MLA | Tan, Sujian,et al."Molluskan Dorsal-Ventral Patterning Relying on BMP2/4 and Chordin Provides Insights into Spiralian Development and Evolution".MOLECULAR BIOLOGY AND EVOLUTION 39.1(2022):18. |
入库方式： OAI收割
来源：海洋研究所
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