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Divergences of the RLR Gene Families across Lophotrochozoans: Domain Grafting, Exon-Intron Structure, Expression, and Positive Selection

文献类型：期刊论文

作者Yao, Shanshan1,2,4,5,6; Chan, Jiulin1,2,5,6; Xu, Yue1,2,5,6; Wu, Shimei4; Zhang, Linlin1,2,3,5,6
刊名INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
出版日期2022-04-01
卷号23期号:7页码:20
关键词RIG-I-like receptor lophotrochozoan innate immune molecular evolution gene expression domain grafting exon-intron structure positive selection
DOI10.3390/ijms23073415
通讯作者Zhang, Linlin(linlinzhang@qdio.ac.cn)
英文摘要Invertebrates do not possess adaptive immunity but have evolved a variety of unique repertoires of innate immune sensors. In this study, we explored the immune diversity and specificity of invertebrates based on the lophotrochozoan RLRs, a major component in antiviral immune recognition. By annotating RLRs in the genomes of 58 representative species across metazoan evolution, we explored the gene expansion of RLRs in Lophotrochozoa. Of note, the N-terminal domains of lophotrochozoan RLRs showed the most striking diversity which evolved independently by domain grafting. Exon-intron structures were revealed to be prevalent in the domain grafting of lophotrochozoan RLRs based on an analysis of sibling paralogs and orthologs. In more than half of the cases, the mechanism of 'exonization/pseudoexonization' led to the generation of non-canonical N-terminal domains. Transcriptomic studies revealed that many non-canonical RLRs display immune-related expression patterns. Two of these RLRs showed obvious evidence of positive selection, which may be the result of host defense selection pressure. Overall, our study suggests that the complex and unique domain arrangement of lophotrochozoan RLRs might result from domain grafting, exon-intron divergence, expression diversification, and positive selection, which may have led to functionally distinct lophotrochozoan RLRs.
资助项目National Natural Science Foundation of China[41976088] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB42000000] ; Key Development Project of Centre for Ocean Mega-Research of Science, Chinese Academy of Science[COMS2019R01]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
出版者MDPI
WOS记录号WOS:000781023800001
源URL[http://ir.qdio.ac.cn/handle/337002/178711]  
专题海洋研究所_实验海洋生物学重点实验室
海洋研究所_深海极端环境与生命过程研究中心
通讯作者Zhang, Linlin
作者单位1.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Megasci, Ctr Deep Sea Res, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Coll Marine Sci, Beijing 100049, Peoples R China
4.Qingdao Univ, Coll Life Sci, Qingdao 266071, Peoples R China
5.Chinese Acad Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
6.Chinese Acad Sci, CAS, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714		 Yao, Shanshan,Chan, Jiulin,Xu, Yue,et al. Divergences of the RLR Gene Families across Lophotrochozoans: Domain Grafting, Exon-Intron Structure, Expression, and Positive Selection[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(7):20.
APA Yao, Shanshan,Chan, Jiulin,Xu, Yue,Wu, Shimei,&Zhang, Linlin.(2022).Divergences of the RLR Gene Families across Lophotrochozoans: Domain Grafting, Exon-Intron Structure, Expression, and Positive Selection.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(7),20.
MLA Yao, Shanshan,et al."Divergences of the RLR Gene Families across Lophotrochozoans: Domain Grafting, Exon-Intron Structure, Expression, and Positive Selection".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.7(2022):20.

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来源：海洋研究所

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