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Chevalinulins A and B, Proangiogenic Alkaloids with a Spiro[bicyclo[2.2.2]octane-diketopiperazine] Skeleton from Deep-Sea Cold-Seep-Derived Fungus Aspergillus chevalieri CS-122 br

文献类型：期刊论文

作者Yan, Li-Hong2,3,4,5; Li, Pei-Hai1; Li, Xiao-Ming2,4,5; Yang, Sui-Qun2,4,5; Liu, Ke-Chun1; Wang, Bin-Gui2,3,4,5; Li, Xin2,4,5
刊名ORGANIC LETTERS
出版日期2022-04-15
卷号24期号:14页码:2684-2688
ISSN号1523-7060
DOI10.1021/acs.orglett.2c00781
通讯作者Wang, Bin-Gui(wangbg@ms.qdio.ac.co) ; Li, Xin(lixin@qdio.ac.cn)
英文摘要Chevalinulins A (1)andB(2), two indolediketopiperazine alkaloids containing an unprecedented spiro-[bicyclo[2.2.2]octane-diketopiperazine] skeleton, together with aknown analogue neoechinulin B (3), were isolated from the deep-sea cold-seep-derived fungusAspergillus chevalieriCS-122. Theirstructures were determined by spectroscopic analysis, single-crystalX-ray diffraction, specific rotation (SR), and NMR calculations.Compounds1and2exhibited significantin vivoproangiogenicactivity in transgenic zebrafish.
资助项目National Natural Science Foundation of China[42076090] ; National Natural Science Foundation of China[U2006203] ; Senior User Project of RV KEXUE[KEXUE2020GZ02] ; National Key R&D Program of China[2018YFC0310800] ; Shandong Provincial Natural Science Foundation[ZR2021ZD28]
WOS研究方向Chemistry
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000791817200020
源URL[http://ir.qdio.ac.cn/handle/337002/179170]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Wang, Bin-Gui; Li, Xin
作者单位1.Qilu Univ Technol, Engn Res Ctr Zebrafish Models Human Dis & Drug Sc, Biol Inst,Key Lab Biosensor Shandong Prov, Shandong Acad Sci,Shandong Prov Engn Lab Biol Tes, Jinan 250103, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Coll Marine Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Qingdao 266071, Peoples R China
5.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714		 Yan, Li-Hong,Li, Pei-Hai,Li, Xiao-Ming,et al. Chevalinulins A and B, Proangiogenic Alkaloids with a Spiro[bicyclo[2.2.2]octane-diketopiperazine] Skeleton from Deep-Sea Cold-Seep-Derived Fungus Aspergillus chevalieri CS-122 br[J]. ORGANIC LETTERS,2022,24(14):2684-2688.
APA Yan, Li-Hong.,Li, Pei-Hai.,Li, Xiao-Ming.,Yang, Sui-Qun.,Liu, Ke-Chun.,...&Li, Xin.(2022).Chevalinulins A and B, Proangiogenic Alkaloids with a Spiro[bicyclo[2.2.2]octane-diketopiperazine] Skeleton from Deep-Sea Cold-Seep-Derived Fungus Aspergillus chevalieri CS-122 br.ORGANIC LETTERS,24(14),2684-2688.
MLA Yan, Li-Hong,et al."Chevalinulins A and B, Proangiogenic Alkaloids with a Spiro[bicyclo[2.2.2]octane-diketopiperazine] Skeleton from Deep-Sea Cold-Seep-Derived Fungus Aspergillus chevalieri CS-122 br".ORGANIC LETTERS 24.14(2022):2684-2688.

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来源：海洋研究所

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