Verrucosidin Derivatives from the Deep Sea Cold-Seep-Derived Fungus Penicillium polonicum CS-252
文献类型：期刊论文
| 作者 | Li, Yanhe2,3,4 ; Li, Xiaoming3,4; Li, Xin3,4; Yang, Suiqun3,4; Wang, Bingui1,2,3,4; Li, Honglei3,4
|
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2022-05-01 |
| 卷号 | 23期号:10页码:11 |
| 关键词 | deep-sea-derived fungus Penicillium polonicum verrucosidin derivatives structure elucidation antimicrobial activity |
| DOI | 10.3390/ijms23105567 |
| 通讯作者 | Wang, Bingui(wangbg@ms.qdio.ac.cn) ; Li, Honglei(lihonglei@qdio.ac.cn) |
| 英文摘要 | Six novel verrucosidin derivatives, namely, poloncosidins A-F (1-6), together with one known analogue (7), were isolated and identified from the deep-sea-derived fungus Penicillium polonicum CS-252, which was obtained from cold-seep sediments collected in the South China Sea at a depth of 1183 m. Their structures were mainly established on the basis of a detailed interpretation of NMR spectroscopic and mass spectrometric data. The relative and absolute configurations of compounds 1-6 were determined by ECD calculations and a DP4+ probability analysis. Compounds 1-5 represent the first examples of verrucosidins with a 2,5-dihydrofuran ring which is uncommon among the known analogues. These compounds exhibited inhibitory activities against several human and aquatic pathogens with MIC values ranging from 4 to 32 mu g/mL. |
| 资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDA22050401] ; National Natural Science Foundation of China[U2006203] ; National Natural Science Foundation of China[42076090] ; Shandong Provincial Natural Science Foundation[ZR2021ZD28] ; Senior User Project of RV KEXUE[KEXUE2020GZ02] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000801608100001 |
| 出版者 | MDPI |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/179311]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wang, Bingui; Li, Honglei |
| 作者单位 | 1.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Coll Marine Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yanhe,Li, Xiaoming,Li, Xin,et al. Verrucosidin Derivatives from the Deep Sea Cold-Seep-Derived Fungus Penicillium polonicum CS-252[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(10):11. |
| APA | Li, Yanhe,Li, Xiaoming,Li, Xin,Yang, Suiqun,Wang, Bingui,&Li, Honglei.(2022).Verrucosidin Derivatives from the Deep Sea Cold-Seep-Derived Fungus Penicillium polonicum CS-252.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(10),11. |
| MLA | Li, Yanhe,et al."Verrucosidin Derivatives from the Deep Sea Cold-Seep-Derived Fungus Penicillium polonicum CS-252".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.10(2022):11. |
入库方式： OAI收割
来源：海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。