Transcriptome Analysis of the Nematodes Caenorhabditis elegans and Litoditis marina in Different Food Environments
文献类型：期刊论文
| 作者 | Sun, Peiqi1,2,3,4 ; Cao, Xuwen1,2,3,4; Zhang, Liusuo1,3,4
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| 刊名 | JOURNAL OF MARINE SCIENCE AND ENGINEERING
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| 出版日期 | 2022-05-01 |
| 卷号 | 10期号:5页码:18 |
| 关键词 | C. elegans L. marina lifespan development FOXO DAF-16 lysosome |
| DOI | 10.3390/jmse10050580 |
| 通讯作者 | Zhang, Liusuo(lzhang@qdio.ac.cn) |
| 英文摘要 | Diets regulate animal development, reproduction, and lifespan. However, the underlying molecular mechanisms remain elusive. We previously showed that a chemically defined CeMM diet attenuates the development and promotes the longevity of C. elegans, but whether it impacts other nematodes is unknown. Here, we studied the effects of the CeMM diet on the development and longevity of the marine nematode Litoditis marina, which belongs to the same family as C. elegans. We further investigated genome-wide transcriptional responses to the CeMM and OP50 diets for both nematodes, respectively. We observed that the CeMM diet attenuated L. marina development but did not extend its lifespan. Through KEEG enrichment analysis, we found that many of the FOXO DAF-16 signaling and lysosome and xenobiotic metabolism related genes were significantly increased in C. elegans on the CeMM diet, which might contribute to the lifespan extension of C. elegans. Notably, we found that the expression of lysosome and xenobiotic metabolism pathway genes was significantly down-regulated in L. marina on CeMM, which might explain why the CeMM diet could not promote the lifespan of L. marina compared to bacterial feeding. Additionally, the down-regulation of several RNA transcription and protein generation and related processes genes in C. elegans on CeMM might not only be involved in extending longevity, but also contribute to attenuating the development of C. elegans on the CeMM diet, while the down-regulation of unsaturated fatty acids synthesis genes in L. marina might contribute to slow down its growth while on CeMM. This study provided important insights into how different diets regulate development and lifespan, and further genetic analysis of the candidate gene(s) of development and longevity will facilitate exploring the molecular mechanisms underlying how diets regulate animal physiology and health in the context of variable nutritional environments. |
| 资助项目 | National Key R and D Program of China[2018YFD0901301] ; Talents from overseas Program, IOCAS of the Chinese Academy of Sciences ; Qingdao Innovation Leadership Program[16-8-3-19-zhc] ; Key deployment project of the Centre for Ocean Mega-Research of Science, Chinese Academy of Sciences[COMS2019Q16] |
| WOS研究方向 | Engineering ; Oceanography |
| 语种 | 英语 |
| WOS记录号 | WOS:000801679000001 |
| 出版者 | MDPI |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/179362]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Zhang, Liusuo |
| 作者单位 | 1.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nankai Rd, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Peiqi,Cao, Xuwen,Zhang, Liusuo. Transcriptome Analysis of the Nematodes Caenorhabditis elegans and Litoditis marina in Different Food Environments[J]. JOURNAL OF MARINE SCIENCE AND ENGINEERING,2022,10(5):18. |
| APA | Sun, Peiqi,Cao, Xuwen,&Zhang, Liusuo.(2022).Transcriptome Analysis of the Nematodes Caenorhabditis elegans and Litoditis marina in Different Food Environments.JOURNAL OF MARINE SCIENCE AND ENGINEERING,10(5),18. |
| MLA | Sun, Peiqi,et al."Transcriptome Analysis of the Nematodes Caenorhabditis elegans and Litoditis marina in Different Food Environments".JOURNAL OF MARINE SCIENCE AND ENGINEERING 10.5(2022):18. |
入库方式： OAI收割
来源：海洋研究所
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