Jellyfish Nemopilema nomurai causes myotoxicity through the metalloprotease component of venom
文献类型：期刊论文
| 作者 | Li, Aoyu1,2,3; Yu, Huahua1,2 ; Li, Rongfeng1,2; Yue, Yang1,2; Yu, Chunlin1,2,3; Geng, Hao1,2,3; Liu, Song1,2; Xing, Ronge1,2; Li, Pengcheng1,2
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| 刊名 | BIOMEDICINE & PHARMACOTHERAPY
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| 出版日期 | 2022-07-01 |
| 卷号 | 151页码:8 |
| ISSN号 | 0753-3322 |
| 关键词 | Jellyfish envenomation Nemopilema nomurai nematocyst venom (NnNV) Myotoxicity Metalloprotease |
| DOI | 10.1016/j.biopha.2022.113192 |
| 通讯作者 | Yu, Huahua(yuhuahua@qdio.ac.cn) |
| 英文摘要 | Jellyfish envenomation is a common medical problem in many countries. However, the myotoxicity and effector molecules of scyphozoan venoms remain uninvestigated. Here, we present the myotoxicity of nematocyst venom from Nemopilema nomurai (NnNV), a giant venomous scyphozoan from China, for the first time, using in vivo models with inhibitors. NnNV was able to induce remarkable myotoxicity including significant muscle swelling, increasing the content of CK and LDH in serum, stimulating inflammation of muscle tissue, and destroying the structure of muscle tissue. In addition, the metalloproteinase inhibitors BMT and EDTA significantly reduced the myotoxicity induced by NnNV. Moreover, BMT and EDTA could decrease the inflammatory stimulation and necrosis of muscle tissue caused by the venom. These observations suggest that the metalloproteinase components of NnNV make a considerable contribution to myotoxicity. This study contributes to understanding the effector molecules of muscle injury caused by jellyfish stings and suggests a new idea for the treatment of scyphozoan envenomation. |
| 资助项目 | National Key R&D Program of China[2017YFE0111100-04] ; National Key R&D Program of China[2019YFC0312605] ; National Natural Sci-ence Foundation of China[41776163] ; National Natural Sci-ence Foundation of China[41876164] ; Major Projects on the Transformation of Old and Novel Kinetic Energy of Shandong Province[2020-1220] ; Natural Science Foundation of Shandong Province[ZR2019QD012] |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| WOS记录号 | WOS:000807392900004 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/179434]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Yu, Huahua |
| 作者单位 | 1.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Aoyu,Yu, Huahua,Li, Rongfeng,et al. Jellyfish Nemopilema nomurai causes myotoxicity through the metalloprotease component of venom[J]. BIOMEDICINE & PHARMACOTHERAPY,2022,151:8. |
| APA | Li, Aoyu.,Yu, Huahua.,Li, Rongfeng.,Yue, Yang.,Yu, Chunlin.,...&Li, Pengcheng.(2022).Jellyfish Nemopilema nomurai causes myotoxicity through the metalloprotease component of venom.BIOMEDICINE & PHARMACOTHERAPY,151,8. |
| MLA | Li, Aoyu,et al."Jellyfish Nemopilema nomurai causes myotoxicity through the metalloprotease component of venom".BIOMEDICINE & PHARMACOTHERAPY 151(2022):8. |
入库方式： OAI收割
来源：海洋研究所
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