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Structural Characterization of Gracilariopsis lemaneiformis Polysaccharide and Its Property in Delaying Cellular Senescence

文献类型：期刊论文

作者Wang, Xiaomei3; Xu, Xiaogang1,2; Mao, Genxiang1,2; Guo, Yue3; Wang, Guangce5,6; Sun, Xue4; Xu, Nianjun4; Zhang, Zhongshan3
刊名FRONTIERS IN NUTRITION
出版日期2022-05-16
卷号9页码:12
ISSN号2296-861X
关键词G. lemaneiformis polysaccharide cellular senescence SA-beta-gal p53-p21 pathway
DOI10.3389/fnut.2022.876992
通讯作者Mao, Genxiang(maogenxiang@163.com) ; Xu, Nianjun(xunianjun@nbu.edu.cn) ; Zhang, Zhongshan(01959@zjhu.edu.cn)
英文摘要The sulfated polysaccharide was isolated from the purified G. lemaneiformis polysaccharide (PGP), and its property in delaying H2O2-induced 2BS cellular senescence was studied. The results showed that PGP was a linear polysaccharide containing alternating alpha-(1 -> 3)-and beta-(1 -> 4)-galactopyranose units. Most of the sulfate groups are at C6 of the-(1 -> 4)-alpha-D-Galp, and a small part of them are at C3 and C6. PGP pretreatment could decrease SA-beta-gal-positive cells and prevent the formation of senescence-associated heterochromatic foci (SAHF) induced by H2O2 in a dose-dependent manner. It is speculated that PGP may delay aging by downregulating the expression of p21 and p53 genes. The finding provides new insights into the beneficial role of G. lemaneiformis polysaccharide (GP) on retarding senescence process.
资助项目Zhejiang Province Basic public welfare research project[LGN21D060001] ; National Natural Science Foundation of China[31700307] ; National Natural Science Foundation of China[81771520]
WOS研究方向Nutrition & Dietetics
语种英语
出版者FRONTIERS MEDIA SA
WOS记录号WOS:000804429200001
源URL[http://ir.qdio.ac.cn/handle/337002/179464]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Mao, Genxiang; Xu, Nianjun; Zhang, Zhongshan
作者单位1.Zhejiang Hosp, Geriatr Inst Zhejiang Prov, Dept Geriatr, Hangzhou, Peoples R China
2.Zhejiang Hosp, Key Labof Geriatr, Dept Geriatr, Hangzhou, Peoples R China
3.Huzhou Univ, Key Lab Vector Biol & Pathogen Control Zhejiang Pr, Huzhou, Peoples R China
4.Ningbo Univ, Collaborat Innovat Ctr Zhejiang Marine High Effici, Natl Engn Res Lab Marine Biotechnol & Engn, Key Lab Aquacultural Biotechnol,Minist Educ,Key La, Ningbo, Peoples R China
5.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
6.Chinese Acad Sci, Qingdao, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Xiaomei,Xu, Xiaogang,Mao, Genxiang,et al. Structural Characterization of Gracilariopsis lemaneiformis Polysaccharide and Its Property in Delaying Cellular Senescence[J]. FRONTIERS IN NUTRITION,2022,9:12.
APA Wang, Xiaomei.,Xu, Xiaogang.,Mao, Genxiang.,Guo, Yue.,Wang, Guangce.,...&Zhang, Zhongshan.(2022).Structural Characterization of Gracilariopsis lemaneiformis Polysaccharide and Its Property in Delaying Cellular Senescence.FRONTIERS IN NUTRITION,9,12.
MLA Wang, Xiaomei,et al."Structural Characterization of Gracilariopsis lemaneiformis Polysaccharide and Its Property in Delaying Cellular Senescence".FRONTIERS IN NUTRITION 9(2022):12.

入库方式： OAI收割

来源：海洋研究所

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