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Genome-wide analysis of the hard clam mitogen-activated protein kinase kinase gene family and their transcriptional profiles under abiotic stress

文献类型：期刊论文

作者Hu, Zhi3,4,8,9,10,11; Song, Hao3,4,8,9,10; Feng, Jie3,4,8,9,10; Zhou, Cong3,4,8,9,10,11; Yang, Mei-Jie3,4,8,9,10; Shi, Pu3,4,8,9,10,11; Yu, Zheng-Lin2; Li, Yong-Ren7; Guo, Yong-Jun7; Li, Hai-Zhou1
刊名MARINE ENVIRONMENTAL RESEARCH
出版日期2022-04-01
卷号176页码:10
ISSN号0141-1136
关键词Mercenaria mercenaria MAPKK gene family Transcriptional profiles Abiotic stress
DOI10.1016/j.marenvres.2022.105606
通讯作者Zhang, Tao(tzhang@qdio.ac.cn)
英文摘要Mitogen-activated protein kinase kinase (MAPKK) was the hub component of the Mitogen-activated protein kinase (MAPK) signaling pathway and played an important role in the cellular response to environmental stress. In this study, we identified five MmMAPKK genes in hard clam Mercenaria mercenaria and found that all MmMAPKK genes contain a conserved protein kinase domain. The MmMAPKK genes derived from dispersed duplication were unevenly distributed in three chromosomes. Although the genome size was highly variable among different bivalve mollusks, the number of MAPKK genes was relatively stable. Phylogenetic analysis showed that bivalve MAPKK was divided into five clades, and amino acid sequences of MAPKK from the same clade consisted of similar conserved motifs. The syntenic analysis demonstrated that MmMAPKKs had the highest number of homologous gene pairs with Cyclina sinensis. MmMAPKKs were ubiquitously expressed in all examined tissues, and all MmMAPKK genes were highly expressed in the ovary. MmMAPKK genes showed stress-specific expression under envirionmental stress. MmMAPKK7 showed an upregulated in heat and heat plus hypoxia stress while MmMAPKK1 showed an upregulated in hypoxic stress groups. Dynamic changes of MmMAPKK7, MmMAPKK6 and MmMAPKK1 in hemocytes were observed in response to air exposure. MmMAPKK4 significantly downregulated after air exposure for five days. MmMAPKK7 and MmMAPKK6 might participate in adaptation to low salinity stress. Our results provided useful information about MAPKK and laid a foundation for further studies on MAPKK evolution in the bivalve.
资助项目China National Key RD Program[2019YFD0900800] ; Tianjin science and technology commission project[20YFZCSN00240] ; Tianjin Agricultural Committee Project[202103010] ; Shandong Province Agricultural Major Applied Technology Innovation Project[SF1405303301] ; Taishan Industrial Leading Talents Project[LJNY201704] ; 'Double Hundred' Blue Industry Leader Team of Yantai ; Creative Team Project of the Laboratory for Marine Ecology and Environmental Science, Qingdao Pilot National Laboratory for Marine Science and Technology[LMEES-CTSP-2018-1] ; China Agriculture Research System of MOF and MARA
WOS研究方向Environmental Sciences & Ecology ; Marine & Freshwater Biology ; Toxicology
语种英语
出版者ELSEVIER SCI LTD
WOS记录号WOS:000795140000006
源URL[http://ir.qdio.ac.cn/handle/337002/179251]  
专题海洋研究所_海洋生态与环境科学重点实验室
通讯作者Zhang, Tao
作者单位1.Shandong Fu Han Ocean Sci Tech Co Ltd, Haiyang 265100, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
3.Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
5.Chinese Univ Hong Kong, Shenzhen 518172, Peoples R China
6.Qingdao 58 High Sch Shandong Prov, Qingdao 262000, Peoples R China
7.Tianjin Agr Univ, Fisheries Coll, Tianjin Key Lab Aqua Ecol & Aquaculture, Tianjin 300384, Peoples R China
8.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China
9.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
10.Chinese Acad Sci, Inst Oceanol, CAS Engn Lab Marine Ranching, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714		 Hu, Zhi,Song, Hao,Feng, Jie,et al. Genome-wide analysis of the hard clam mitogen-activated protein kinase kinase gene family and their transcriptional profiles under abiotic stress[J]. MARINE ENVIRONMENTAL RESEARCH,2022,176:10.
APA Hu, Zhi.,Song, Hao.,Feng, Jie.,Zhou, Cong.,Yang, Mei-Jie.,...&Zhang, Tao.(2022).Genome-wide analysis of the hard clam mitogen-activated protein kinase kinase gene family and their transcriptional profiles under abiotic stress.MARINE ENVIRONMENTAL RESEARCH,176,10.
MLA Hu, Zhi,et al."Genome-wide analysis of the hard clam mitogen-activated protein kinase kinase gene family and their transcriptional profiles under abiotic stress".MARINE ENVIRONMENTAL RESEARCH 176(2022):10.

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来源：海洋研究所

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