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3D printing of MXene composite hydrogel scaffolds for photothermal antibacterial activity and bone regeneration in infected bone defect models

文献类型：期刊论文

作者Nie, Ran3,4; Sun, Yue3,4; Lv, Huixin3,4; Lu, Ming1,2; Huangfu, Huimin3,4; Li, Yangyang3,4; Zhang, Yidi3,4; Wang, Dongyang3; Wang, Lin3,4; Zhou, Yanmin3,4
刊名NANOSCALE
出版日期2022-06-09
卷号14期号:22页码:8112-8129
ISSN号2040-3364
DOI10.1039/d2nr02176e
通讯作者Zhou, Yanmin(zhouym@jlu.edu.cn)
英文摘要The repair of infected bone defects with irregular shapes is still a challenge in clinical work. Infected bone defects are faced with several major concerns: the complex shapes of bone defects, intractable bacterial infection and insufficient osseointegration. To solve these problems, we developed a personalized MXene composite hydrogel scaffold GelMA/beta-TCP/sodium alginate (Sr2+)/MXene (Ti3C2) (GTAM) with photothermal antibacterial and osteogenic abilities by 3D printing. In vitro, GTAM scaffolds could kill both Gram-positive and Gram-negative bacteria by NIR irradiation due to the excellent photothermal effects of MXene. Furthermore, rat bone marrow mesenchymal stem cells were mixed into GTAM bioinks for 3D bioprinting. The cell-laden 3D printed GTAM scaffolds showed biocompatibility and bone formation ability depending on MXene, crosslinked Sr2+, and beta-TCP. In vivo, we implanted 3D printed GTAM scaffolds in S. aureus-infected mandible defects of rats with NIR irradiation. GTAM scaffolds could accelerate the healing of infection and bone regeneration, and play synergistic roles in antibacterial and osteogenic effects. This study not only provides a strategy for the precise osteogenesis of infected bone defects, but also broadens the biomedical applications of MXene photothermal materials.
资助项目National Natural Science Foundation of China[82071152] ; Department of Finance of Jilin Province[JCSZ2020304-1] ; Department of Science and Technology of Jilin Province[20160101138JC]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
出版者ROYAL SOC CHEMISTRY
WOS记录号WOS:000802331000001
资助机构National Natural Science Foundation of China ; Department of Finance of Jilin Province ; Department of Science and Technology of Jilin Province
源URL[http://ir.imr.ac.cn/handle/321006/174182]  
专题金属研究所_中国科学院金属研究所
通讯作者Zhou, Yanmin
作者单位1.Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China
2.Jilin Normal Univ, Key Lab Funct Mat Phys & Chem, Joint Lab MXene Mat, Minist Educ, Changchun 130103, Jilin, Peoples R China
3.Jilin Univ, Hosp Stomatol, Jilin Prov Key Lab Tooth Dev & Bone Remodeling, Changchun 130021, Peoples R China
4.Jilin Univ, Hosp Stomatol, Dept Oral Implantol, Changchun 130021, Peoples R China
推荐引用方式
GB/T 7714		 Nie, Ran,Sun, Yue,Lv, Huixin,et al. 3D printing of MXene composite hydrogel scaffolds for photothermal antibacterial activity and bone regeneration in infected bone defect models[J]. NANOSCALE,2022,14(22):8112-8129.
APA Nie, Ran.,Sun, Yue.,Lv, Huixin.,Lu, Ming.,Huangfu, Huimin.,...&Zhou, Yanmin.(2022).3D printing of MXene composite hydrogel scaffolds for photothermal antibacterial activity and bone regeneration in infected bone defect models.NANOSCALE,14(22),8112-8129.
MLA Nie, Ran,et al."3D printing of MXene composite hydrogel scaffolds for photothermal antibacterial activity and bone regeneration in infected bone defect models".NANOSCALE 14.22(2022):8112-8129.

入库方式： OAI收割

来源：金属研究所

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