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Mechanisms of Hierarchical Topographies Tuning Bacteria and Cell Biological Responses to the Surfaces of Pure Titanium and Cu-Bearing Titanium Alloy

文献类型：期刊论文

作者Liu, Hui4,5; Xu, Daorong2,3; Ma, Yuan2,3; Qian, Jikun2,3; Yang, Yinghui1; Yu, Bin2,3; Ren, Ling5; Yang, Ke5
刊名ACS APPLIED MATERIALS & INTERFACES
出版日期2022-05-04
卷号14期号:17页码:19226-19240
关键词hierarchical topography copper-bearing titanium alloy surface modi fi cation antibacterial activity osseointegration orthopedic implant
ISSN号1944-8244
DOI10.1021/acsami.2c02802
通讯作者Yu, Bin(yubin@smu.edu.cn) ; Ren, Ling(lren@imr.ac.cn) ; Yang, Ke(kyang@imr.ac.cn)
英文摘要The competition between cells integration and bacterial colonization determines the fate of implantations. To reveal the effects of clinical implant topographies on osteoblast differentiation and bacterial biofilm formation, a series of micron/ submicron/nano-hierarchical structures were created at pure titanium surfaces (Ti-I, Ti-II, Ti-III). It was found that the hierarchical structures promoted MC3T3-E1 cell differentiation through contact guidance and Ti-II processed the best osteogenic ability. Undesirably, hierarchical surfaces further accelerated the biofilm formation due to submicron structures with low interaction. To reduce the risk of bacterial infections, hierarchical structures were prepared on the antibacterial Cu-bearing titanium alloy surfaces (TiCu-I, TiCu-II, TiCu-III). Hierarchical topographies not only endowed TiCu surfaces with antibacterial trapping characteristics due to CuO doped in the outermost oxides layer but also shifted the corrosion behavior of TiCu alloy into activation-passivation, increasing the Cu-ion release rate and further promoting the osteogenic differentiation. TiCu-III possessed excellent antibacterial trapping ability and optimal osteogenic action. Finally, in the osteomyelitis-modeled mice, hierarchical topographies aggravated the bacterial infection around Ti implants, which entirely lost the osseointegration, while all of the TiCu surfaces significantly inhibited the infection and accelerated the formation of new bone tunnels around the implants. In vivo studies successfully confirmed the tuning mechanism of hierarchical topographies on the biological responses of bacteria and cells to the Ti and TiCu alloys, which would pave the way to develop novel biofunctionalized metal implants.
资助项目National Natural Science Foundation[31870954] ; National Natural Science Foundation[51631009] ; National Key Research and Development Program of China[2018YFC1106601] ; National Key Research and Development Program of China[2016YFC1100601] ; Liaoning Revitalization Talents Program[XLYC1807069] ; Key Projects for Foreign Cooperation of Bureau of International Cooperation Chinese Academy of Sciences[174321KYSB20180006]
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000813013100001
出版者AMER CHEMICAL SOC
资助机构National Natural Science Foundation ; National Key Research and Development Program of China ; Liaoning Revitalization Talents Program ; Key Projects for Foreign Cooperation of Bureau of International Cooperation Chinese Academy of Sciences
源URL[http://ir.imr.ac.cn/handle/321006/174410]  
专题金属研究所_中国科学院金属研究所
通讯作者Yu, Bin; Ren, Ling; Yang, Ke
作者单位1.Silvan Med Ltd, Suzhou 215006, Peoples R China
2.Southern Med Univ, Nanfang Hosp, Guangdong Prov Key Lab Bone & Cartilage Regenerat, Guangzhou 510515, Peoples R China
3.Southern Med Univ, Nanfang Hosp, Dept Orthopaed, Div Orthopaed Surg, Guangzhou 510515, Peoples R China
4.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China
5.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, Shenyang 110016, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Hui,Xu, Daorong,Ma, Yuan,et al. Mechanisms of Hierarchical Topographies Tuning Bacteria and Cell Biological Responses to the Surfaces of Pure Titanium and Cu-Bearing Titanium Alloy[J]. ACS APPLIED MATERIALS & INTERFACES,2022,14(17):19226-19240.
APA Liu, Hui.,Xu, Daorong.,Ma, Yuan.,Qian, Jikun.,Yang, Yinghui.,...&Yang, Ke.(2022).Mechanisms of Hierarchical Topographies Tuning Bacteria and Cell Biological Responses to the Surfaces of Pure Titanium and Cu-Bearing Titanium Alloy.ACS APPLIED MATERIALS & INTERFACES,14(17),19226-19240.
MLA Liu, Hui,et al."Mechanisms of Hierarchical Topographies Tuning Bacteria and Cell Biological Responses to the Surfaces of Pure Titanium and Cu-Bearing Titanium Alloy".ACS APPLIED MATERIALS & INTERFACES 14.17(2022):19226-19240.

入库方式： OAI收割

来源：金属研究所

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