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Synthesis of Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Thioctate and the Potential for Antioxidant Application

文献类型：期刊论文

作者Tan, Wenqiang2,3; Lin, Conghao1; Zhang, Jingjing2,3; Li, Qing2,3; Guo, Zhanyong2,3
刊名MOLECULES
出版日期2022-05-01
卷号27期号:9页码:13
关键词hydroxypropyltrimethyl ammonium chitosan derivatives alpha-lipoic acid antioxidant activity
DOI10.3390/molecules27092682
通讯作者Guo, Zhanyong(zyguo@yic.ac.cn)
英文摘要Hydroxypropyltrimethyl ammonium chloride chitosan (HACC) is one of the most important water-soluble chitosan derivatives; its derivatives have gained growing attention due to their potential biomedical applications. Here, hydroxypropyltrimethyl ammonium chitosan derivatives bearing thioctate (HACTs), with different degrees of substitution of thioctate, were prepared using HACC and alpha-lipoic acid as the reaction precursors, using an ion exchange method. The structural characteristics of the synthesized derivatives were confirmed by FTIR, H-1 NMR, and C-13 NMR spectroscopy. In addition, their antioxidant behaviors were also investigated in vitro by the assays of reducing power, and scavenging activities against hydroxyl radicals and DPPH radicals. The antioxidant assay indicated that HACTs displayed strong antioxidant activity compared with HACC, especially in terms of reducing power. Besides, the antioxidant activities of the prepared products were further enhanced with the increase in the test concentration and the degrees of substitution of thioctate. At the maximum test concentration of 1.60 mg/mL, the absorbance value at 700 nm of HACTs, under the test conditions, was 4.346 +/- 0.296, while the absorbance value of HACC was 0.041 +/- 0.007. The aforementioned results support the use of HACTs as antioxidant biomaterials in food and the biomedical field.
WOS关键词ALPHA-LIPOIC ACID ; CARBOXYMETHYL CHITOSAN ; ENHANCED ANTIOXIDANT ; ANTIFUNGAL ; POLYSACCHARIDES ; DESIGN
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000796152900001
资助机构Natural Science Foundation of Shandong Province of China ; Youth Innovation Promotion Association CAS ; National Key Research and Development Program of China
源URL[http://ir.yic.ac.cn/handle/133337/31074]  
专题海岸带生物学与生物资源利用重点实验室
烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
海岸带生物资源高效利用研究与发展中心
通讯作者Guo, Zhanyong
作者单位1.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
3.Chinese Acad Sci, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714		 Tan, Wenqiang,Lin, Conghao,Zhang, Jingjing,et al. Synthesis of Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Thioctate and the Potential for Antioxidant Application[J]. MOLECULES,2022,27(9):13.
APA Tan, Wenqiang,Lin, Conghao,Zhang, Jingjing,Li, Qing,&Guo, Zhanyong.(2022).Synthesis of Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Thioctate and the Potential for Antioxidant Application.MOLECULES,27(9),13.
MLA Tan, Wenqiang,et al."Synthesis of Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Thioctate and the Potential for Antioxidant Application".MOLECULES 27.9(2022):13.

入库方式： OAI收割

来源：烟台海岸带研究所

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