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Impaired central set point of thyroid homeostasis during quetiapine treatment in the acute phase of schizophrenia

文献类型：期刊论文

作者Zhao, Ying13,14,15; Guan, Qiongge12; Shi, Jingyi14; Sun, Jiewei14; Wang, Qi15; Yang, Jianzhou11,13; Retnakaran, Ravi9,10; Han, Jinhong8; Zhang, Xiangyang7,15; Hao, Wei15
刊名SCHIZOPHRENIA RESEARCH
出版日期2022-03-01
卷号241页码:244-250
ISSN号0920-9964
关键词Quetiapine Thyroid homeostasis Central set point Schizophrenia
DOI10.1016/j.schres.2022.02.010
通讯作者Huang, Xin(Xin.huang@hunnu.edu.cn) ; Zhang, Ruiling(zhangruilingxx@163.com) ; Zhai, Desheng(zds@xxmu.edu.cn)
英文摘要Aim: To evaluate the impact of quetiapine treatment on central set point of thyroid homeostasis in patients with acute phase schizophrenia. Methods: During Jan. 2016 to Dec. 2018, we conducted a retrospective cohort study in "the Second Affiliated Hospital of Xinxiang Medical University". All patients admitted for treatment of schizophrenia being euthyroid at admission and reevaluated for thyroid function during hospitalization were recruited and followed until discharge. Patients treated with mood stabilizers during hospitalization were excluded. Quetiapine use was the exposure measure. The primary outcomes were the parameters of central set point of thyroid homeostasis measured by "thyroid-stimulating hormone (TSH) index" and "thyroid feedback quantile-based index (TFQI)". Multiple regression models were used to estimate the association between quetiapine exposure and outcomes. Results: A total of 1302 patients were enrolled in this study. Quetiapine exposure was associated with a more significant decline in the TSH index and TFQI, and the adjusted beta and 95% confidence interval (CI) were -0.12 (-0.22, -0.01) and -0.10 (-0.15, -0.05), respectively. A dose-response association between quetiapine exposure and decline in TSH index and TFQI was observed (P < 0.05). Sensitivity analyses restricting to patients under mono-atypical antipsychotic therapy, or selecting patients in the non-quetiapine group matched to quetiapine group yielded similar results. Conclusion: Quetiapine was associated with TSH index and TFQI reduction in a dose-response pattern, suggesting that impaired central set point may be involved in the mechanism by which quetiapine affects hypothalamuspituitary-thyroid axis in acute phase schizophrenia patients.
收录类别SCI
WOS关键词FUNCTION TESTS ; HYPOTHYROIDISM ; TSH
资助项目Henan Key Science and Technologies Development Program[212102310102] ; Henan Key Science and Technologies Development Program[202102310084] ; Henan Key Science and Technologies Development Program[202102310085] ; Support Project of Scientific and Technological Innovation Team in Universities of Henan Province[20IRTSTHN027] ; Henan Key Medical Science and Technologies Development Program[SBGJ2018058] ; Henan Clinical Research Center for Mental Disorders and Henan Key Laboratory of Biological Psychiatry[2020-zxkfkt-005] ; Henan Clinical Research Center for Mental Disorders and Henan Key Laboratory of Biological Psychiatry[ZDSYS2019008] ; Henan Clinical Research Center for Mental Disorders and Henan Key Laboratory of Biological Psychiatry[ZDSYS2018004]
WOS研究方向Psychiatry
语种英语
出版者ELSEVIER
WOS记录号WOS:000812325300014
资助机构Henan Key Science and Technologies Development Program ; Support Project of Scientific and Technological Innovation Team in Universities of Henan Province ; Henan Key Medical Science and Technologies Development Program ; Henan Clinical Research Center for Mental Disorders and Henan Key Laboratory of Biological Psychiatry
源URL[http://ir.psych.ac.cn/handle/311026/42879]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Huang, Xin; Zhang, Ruiling; Zhai, Desheng
作者单位1.Univ Ottawa, Dept Obstet & Gynecol, Fac Med, Ottawa, ON, Canada
2.Univ Ottawa, Sch Epidemiol & Publ Hlth, Fac Med, Ottawa, ON, Canada
3.Ottawa Hosp Res Inst, Clin Epidemiol Program, OMNI Res Grp, Ottawa, ON, Canada
4.Xinxiang Med Univ, Henan Int Joint Lab Noninvas Neuromodulat, Xinxiang 453003, Henan, Peoples R China
5.Xinxiang Med Univ, Sch Publ Hlth, Xinxiang 453003, Henan, Peoples R China
6.Hunan Normal Univ, Sch Med, Dept Epidemiol, Changsha 410013, Peoples R China
7.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
8.Xinxiang Med Univ, Sch Basic Med, Dept Anat & Histol, Xinxiang 453003, Henan, Peoples R China
9.Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada
10.Univ Toronto, Div Endocrinol & Metab, Toronto, ON, Canada
推荐引用方式
GB/T 7714		 Zhao, Ying,Guan, Qiongge,Shi, Jingyi,et al. Impaired central set point of thyroid homeostasis during quetiapine treatment in the acute phase of schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2022,241:244-250.
APA Zhao, Ying.,Guan, Qiongge.,Shi, Jingyi.,Sun, Jiewei.,Wang, Qi.,...&Wen, Shi Wu.(2022).Impaired central set point of thyroid homeostasis during quetiapine treatment in the acute phase of schizophrenia.SCHIZOPHRENIA RESEARCH,241,244-250.
MLA Zhao, Ying,et al."Impaired central set point of thyroid homeostasis during quetiapine treatment in the acute phase of schizophrenia".SCHIZOPHRENIA RESEARCH 241(2022):244-250.

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来源：心理研究所

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