Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways
文献类型：期刊论文
| 作者 | Bian, Li-hua2,4; Yao, Zi-wei4; Wang, Zhe-yi1,4; Wang, Xiao-mei4; Li, Qiu-yu4; Yang, Xue4; Li, Jia-yuan4; Wei, Xiao-jia4; Wan, Guo-hui4; Wang, Yu-qing4 |
| 刊名 | BIOMEDICINE & PHARMACOTHERAPY
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| 出版日期 | 2022-09-01 |
| 卷号 | 153页码:17 |
| 通讯作者邮箱 | cathybless@163.com (l.-h. bian) ; yaoziwei0000@163.com (z.-w. yao) ; zheyi91@126.com (z.-y. wang) ; 467115394@qq.com (x.-m. wang) ; 18166896895@163.com (q.-y. li) ; 1015190719@qq.com (x. yang) ; ljy15612930585@163.com (j.-y. li) ; 574013385@qq.com (x.-j. wei) ; chenxihui912@126.com (g.-h. wan) ; bucmwangyq@163.com (y.-q. wang) ; shijl@vip.sina.com (j.-l. shi) ; guojy@psych.ac.cn (j.-y. guo) |
| 关键词 | Parkinson?s disease Nardosinone slc38a2 GABAergic synaptic pathway |
| ISSN号 | 0753-3322 |
| DOI | 10.1016/j.biopha.2022.113269 |
| 产权排序 | 2 |
| 文献子类 | 综述 |
| 英文摘要 | In a rotenone-induced Parkinson's disease (PD) rat model, behavioral investigation, pathological examination, inflammatory factor analysis, and mitochondrial structure and function investigation verified the anti-PD efficacy of nardosinone. A combined transcriptome and proteome analysis proposed that the anti-PD target of nardosinone is the slc38a2 gene and may involve the GABAergic synaptic pathway and cAMP-signaling pathway. Analysis of targeted slc38a2 knockout cells and expression of key enzyme-encoding genes in both pathways verified the target and pathways proposed by the 'omics analysis. This further confirms that nardosinone can regulate the slc38a2 gene, a potential new target for the treatment of Parkinson's disease, and plays an anti-PD role through the GABAergic synaptic and cAMP pathways. |
| 收录类别 | SCI |
| WOS关键词 | SUBSTANTIA-NIGRA ; NARDOSTACHYS-JATAMANSI ; INHIBITION ; DEGENERATION ; DOPAMINE ; NEURONS ; DISEASE ; PROTEIN |
| 资助项目 | Institute of Psychology of the Chinese Academy of Sciences - Na-tional Natural Science Foundation of China[81673560] ; National Natural Science Foundation of China[81673560] |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| WOS记录号 | WOS:000815840900001 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 资助机构 | Institute of Psychology of the Chinese Academy of Sciences - Na-tional Natural Science Foundation of China ; National Natural Science Foundation of China |
| 源URL | [http://ir.psych.ac.cn/handle/311026/42925]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Shi, Jin-li; Guo, Jian-you |
| 作者单位 | 1.Shandong Univ, Qilu Hosp, Jinan 250012, Shandong, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A DatunRoad, Beijing 100101, Peoples R China 4.Beijing Univ Chinese Med, Sch Chinese Mat Med, 11A North Third Ring East Rd, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bian, Li-hua,Yao, Zi-wei,Wang, Zhe-yi,et al. Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways[J]. BIOMEDICINE & PHARMACOTHERAPY,2022,153:17. |
| APA | Bian, Li-hua.,Yao, Zi-wei.,Wang, Zhe-yi.,Wang, Xiao-mei.,Li, Qiu-yu.,...&Guo, Jian-you.(2022).Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways.BIOMEDICINE & PHARMACOTHERAPY,153,17. |
| MLA | Bian, Li-hua,et al."Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways".BIOMEDICINE & PHARMACOTHERAPY 153(2022):17. |
入库方式： OAI收割
来源：心理研究所
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