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Resting-state functional connectivity of salience network in schizophrenia and depression

文献类型：期刊论文

作者Huang, Huan5; Chen, Cheng5; Rong, Bei5; Wan, Qirong5; Chen, Jingang4; Liu, Zhongchun5; Zhou, Yuan3; Wang, Gaohua2,5; Wang, Huiling1,4,5
刊名SCIENTIFIC REPORTS
出版日期2022-07-01
卷号12期号:1页码:8
ISSN号2045-2322
DOI10.1038/s41598-022-15489-9
通讯作者Wang, Huiling(hlwang@whu.edu.cn)
英文摘要To explore the salience network (SN) functional alterations in schizophrenia and depression, resting-state functional magnetic resonance imaging (rs-fMRI) data from 29 patients with schizophrenia (SCH), 28 patients with depression (DEP) and 30 healthy controls (HC) were obtained. The SN was derived from data-driven group independent component analysis (gICA). ANCOVA and post hoc tests were performed to discover the FC differences of SN between groups. The ANCOVA demonstrated a significant group effect in FC with right inferior and middle temporal gyrus (ITG and MTG), left caudate, and right precentral gyrus. Post-hoc analyses revealed an opposite altered FC pattern between SN and right ITG and MTG for both patient groups. The DEP group showed a reduced FC between SN and right ITG and MTG compared with HC whereas the SCH group showed an increased FC. In addition, the SCH group showed decreased FC between SN and left caudate, and enhanced FC between SN and right precentral gyrus compared to the other two groups. Our findings suggest distinct FC of SN in schizophrenia and depression, supporting that the resting-state FC pattern of SN may be a transdiagnostic difference between depression and schizophrenia and may play a critical role in the pathogenesis of these two disorders.
收录类别SCI
WOS关键词DEFAULT-MODE NETWORK ; NAIVE PATIENTS ; PSYCHOSIS ; COMMON ; SYMPTOMATOLOGY ; CORTEX ; GYRUS ; RISK
资助项目Fundamental Research Funds for the Central Universities[2042020kf0128] ; Health Commission of Hubei Province scientific research project[WJ2021M142] ; Medical Science Advancement Program of Wuhan University[TFLC2018001]
WOS研究方向Science & Technology - Other Topics
语种英语
出版者NATURE PORTFOLIO
WOS记录号WOS:000819858600064
资助机构Fundamental Research Funds for the Central Universities ; Health Commission of Hubei Province scientific research project ; Medical Science Advancement Program of Wuhan University
源URL[http://ir.psych.ac.cn/handle/311026/42934]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Wang, Huiling
作者单位1.Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Peoples R China
2.Hubei Inst Neurol & Psychiat Res, Wuhan 430060, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
4.Wuhan Univ, Dept Psychiat, Zhongxiang Hosp, Renmin Hosp, Zhongxiang 431900, Peoples R China
5.Wuhan Univ, Dept Psychiat, Renmin Hosp, Wuhan 430060, Peoples R China
推荐引用方式
GB/T 7714		 Huang, Huan,Chen, Cheng,Rong, Bei,et al. Resting-state functional connectivity of salience network in schizophrenia and depression[J]. SCIENTIFIC REPORTS,2022,12(1):8.
APA Huang, Huan.,Chen, Cheng.,Rong, Bei.,Wan, Qirong.,Chen, Jingang.,...&Wang, Huiling.(2022).Resting-state functional connectivity of salience network in schizophrenia and depression.SCIENTIFIC REPORTS,12(1),8.
MLA Huang, Huan,et al."Resting-state functional connectivity of salience network in schizophrenia and depression".SCIENTIFIC REPORTS 12.1(2022):8.

入库方式： OAI收割

来源：心理研究所

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