Mapping lesion, structural disconnection, and functional disconnection to symptoms in semantic aphasia
文献类型：期刊论文
| 作者 | Souter, Nicholas E.6; Wang, Xiuyi5,6; Thompson, Hannah4; Krieger-Redwood, Katya6; Halai, Ajay D.3; Ralph, Matthew A. Lambon3; de Schotten, Michel Thiebaut1,2; Jefferies, Elizabeth6 |
| 刊名 | BRAIN STRUCTURE & FUNCTION
 |
| 出版日期 | 2022-07-04 |
| 页码 | 19 |
| ISSN号 | 1863-2653 |
| 关键词 | Stroke Semantic Aphasia Structural Functional Disconnection |
| DOI | 10.1007/s00429-022-02526-6 |
| 通讯作者 | Souter, Nicholas E.(nes522@york.ac.uk) |
| 英文摘要 | Patients with semantic aphasia have impaired control of semantic retrieval, often accompanied by executive dysfunction following left hemisphere stroke. Many but not all of these patients have damage to the left inferior frontal gyrus, important for semantic and cognitive control. Yet semantic and cognitive control networks are highly distributed, including posterior as well as anterior components. Accordingly, semantic aphasia might not only reflect local damage but also white matter structural and functional disconnection. Here, we characterise the lesions and predicted patterns of structural and functional disconnection in individuals with semantic aphasia and relate these effects to semantic and executive impairment. Impaired semantic cognition was associated with infarction in distributed left-hemisphere regions, including in the left anterior inferior frontal and posterior temporal cortex. Lesions were associated with executive dysfunction within a set of adjacent but distinct left frontoparietal clusters. Performance on executive tasks was also associated with interhemispheric structural disconnection across the corpus callosum. In contrast, poor semantic cognition was associated with small left-lateralized structurally disconnected clusters, including in the left posterior temporal cortex. Little insight was gained from functional disconnection symptom mapping. These results demonstrate that while left-lateralized semantic and executive control regions are often damaged together in stroke aphasia, these deficits are associated with distinct patterns of structural disconnection, consistent with the bilateral nature of executive control and the left-lateralized yet distributed semantic control network. |
| 收录类别 | SCI |
| WOS关键词 | MIDDLE TEMPORAL GYRUS ; FRONTAL ASLANT TRACT ; DISTRIBUTED NETWORK ; COGNITION ; LANGUAGE ; DEFAULT ; DEFICITS ; CONNECTIVITY ; FASCICULUS ; REGIONS |
| 资助项目 | European Research Council[818521] ; European Research Council[GAP: 670428-BRAIN2MIND_NEUROCOMP] ; European Research Council[FLEXSEM-771863] ; Rosetrees Trust[A1699] |
| WOS研究方向 | Anatomy & Morphology ; Neurosciences & Neurology |
| 语种 | 英语 |
| 出版者 | SPRINGER HEIDELBERG |
| WOS记录号 | WOS:000820545300001 |
| 资助机构 | European Research Council ; Rosetrees Trust |
| 源URL | [http://ir.psych.ac.cn/handle/311026/42876]  |
| 专题 | 心理研究所_中国科学院行为科学重点实验室 |
| 通讯作者 | Souter, Nicholas E. |
| 作者单位 | 1.Univ Bordeaux, Inst Malad Neurodegenerat, CEA, CNRS,UMR 5293,Grp Imagerie Neurofonct, Bordeaux, France 2.Sorbonne Univ, Brain Connect & Behav Lab, Paris, France 3.Univ Cambridge, MRC Cognit & Brain Sci Unit, Cambridge, England 4.Univ Reading, Sch Psychol & Clin Language Sci, Reading, Berks, England 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 6.Univ York, Dept Psychol, York YO10 5DD, N Yorkshire, England |
| 推荐引用方式 GB/T 7714 | Souter, Nicholas E.,Wang, Xiuyi,Thompson, Hannah,et al. Mapping lesion, structural disconnection, and functional disconnection to symptoms in semantic aphasia[J]. BRAIN STRUCTURE & FUNCTION,2022:19. |
| APA | Souter, Nicholas E..,Wang, Xiuyi.,Thompson, Hannah.,Krieger-Redwood, Katya.,Halai, Ajay D..,...&Jefferies, Elizabeth.(2022).Mapping lesion, structural disconnection, and functional disconnection to symptoms in semantic aphasia.BRAIN STRUCTURE & FUNCTION,19. |
| MLA | Souter, Nicholas E.,et al."Mapping lesion, structural disconnection, and functional disconnection to symptoms in semantic aphasia".BRAIN STRUCTURE & FUNCTION (2022):19. |
入库方式： OAI收割
来源：心理研究所
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