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Tract-specific white matter microstructural alterations in subjects with schizophrenia and unaffected first-degree relatives

文献类型：期刊论文

作者Xie, Sangma7; Zhuo, Junjie6; Song, Ming3,4,5; Chu, Congying5; Cui, Yue3,4,5; Chen, Yunchun2; Wang, Huaning2; Li, Lihua7; Jiang, Tianzi1,3,4,5
刊名BRAIN IMAGING AND BEHAVIOR
出版日期2022-06-22
页码10
ISSN号1931-7557
关键词Schizophrenia Unaffected first-degree relatives Genetic predisposition White matter tracts Probabilistic tractography
DOI10.1007/s11682-022-00681-2
通讯作者Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn)
英文摘要White matter tracts alterations have been reported in schizophrenia (SZ), but whether such abnormalities are associated with the effects of the disorder itself and/or genetic vulnerability remains unclear. Moreover, the specific patterns of different parts of these altered tracts have been less well studied. Thus, diffusion-weighted images were acquired from 38 healthy controls (HCs), 48 schizophrenia patients, and 33 unaffected first-degree relatives of SZs (FDRs). Diffusion properties of the 25 major tracts automatically extracted with probabilistic tractography were calculated and compared among groups. Regarding the peripheral regions of the tracts, significantly higher diffusivity values in the left superior longitudinal fasciculus (SLF) and the left anterior thalamic radiation (ATR) were observed in SZs than in HCs and unaffected FDRs. However, there were no significant differences between HCs and FDRs in these two tracts. While no main effects of group with respect to the core regions of the 25 tracts survived multiple comparisons correction, FDRs had significantly higher diffusivity values in the left medial lemniscus and lower diffusivity values in the middle cerebellar peduncle than HCs and SZs. These findings enhance the understanding of the abnormal patterns in the peripheral and core regions of the tracts in SZs and those at high genetic risk for schizophrenia. Our results suggest that alterations in the peripheral regions of the left SLF and ATR are features of established illness rather than genetic predisposition, which may serve as critical neural substrates for the psychopathology of schizophrenia.
WOS关键词SUPERIOR LONGITUDINAL FASCICULUS ; ANTERIOR THALAMIC RADIATION ; 1ST-EPISODE SCHIZOPHRENIA ; BIPOLAR DISORDER ; WORKING-MEMORY ; CONNECTIVITY ; INTEGRITY ; DIFFUSIVITY ; HYPOTHESIS ; PATHWAYS
资助项目Natural Science Foundation of Zhejiang Province[LQ19F030012] ; National Natural Science Foundation of China[61901153] ; National Basic Research Program of China (973)[2011CB707800]
WOS研究方向Neurosciences & Neurology
语种英语
出版者SPRINGER
WOS记录号WOS:000814493300001
资助机构Natural Science Foundation of Zhejiang Province ; National Natural Science Foundation of China ; National Basic Research Program of China (973)
源URL[http://ir.ia.ac.cn/handle/173211/49167]  
专题自动化研究所_脑网络组研究中心
通讯作者Jiang, Tianzi
作者单位1.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100190, Peoples R China
2.Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian 710032, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
5.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
6.Hainan Univ, Sch Biomed Engn, Key Lab Biomed Engn Hainan Prov, Haikou 570228, Hainan, Peoples R China
7.Hangzhou Dianzi Univ, Sch Automat, Inst Biomed Engn & Instrumentat, Hangzhou 310018, Peoples R China
推荐引用方式
GB/T 7714		 Xie, Sangma,Zhuo, Junjie,Song, Ming,et al. Tract-specific white matter microstructural alterations in subjects with schizophrenia and unaffected first-degree relatives[J]. BRAIN IMAGING AND BEHAVIOR,2022:10.
APA Xie, Sangma.,Zhuo, Junjie.,Song, Ming.,Chu, Congying.,Cui, Yue.,...&Jiang, Tianzi.(2022).Tract-specific white matter microstructural alterations in subjects with schizophrenia and unaffected first-degree relatives.BRAIN IMAGING AND BEHAVIOR,10.
MLA Xie, Sangma,et al."Tract-specific white matter microstructural alterations in subjects with schizophrenia and unaffected first-degree relatives".BRAIN IMAGING AND BEHAVIOR (2022):10.

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来源：自动化研究所

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