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Reduced Gray Matter Volume in Orbitofrontal Cortex Across Schizophrenia, Major Depressive Disorder, and Bipolar Disorder: A Comparative Imaging Study

文献类型：期刊论文

作者Yang, Yongfeng5,6,7; Li, Xue5,6,7; Cui, Yue2,3,4; Liu, Kang5,6,7; Qu, Haoyang1; Lu, Yanli7; Li, Wenqiang5,6,7; Zhang, Luwen5,6,7; Zhang, Yan5,6,7; Song, Jinggui5,6,7
刊名FRONTIERS IN NEUROSCIENCE
出版日期2022-06-10
卷号16页码:8
关键词schizophrenia major depressive disorder bipolar disorder gray matter volume (GMV) psychopathology
DOI10.3389/fnins.2022.919272
通讯作者Song, Jinggui(songjg62@126.com) ; Lv, Luxian(lvx928@126.com)
英文摘要Schizophrenia (SZ), major depressive disorder (MDD), and bipolar disorder (BD) are severe psychiatric disorders and share common characteristics not only in clinical symptoms but also in neuroimaging. The purpose of this study was to examine common and specific neuroanatomical features in individuals with these three psychiatric conditions. In this study, 70 patients with SZ, 85 patients with MDD, 42 patients with BD, and 95 healthy controls (HCs) were recruited. Voxel-based morphometry (VBM) analysis was used to explore brain imaging characteristics. Psychopathology was assessed using the Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI), the Young Mania Rating Scale (YMRS), and the Positive and Negative Syndrome Scale (PANSS). Cognition was assessed using the digit symbol substitution test (DSST), forward-digital span (DS), backward-DS, and semantic fluency. Common reduced gray matter volume (GMV) in the orbitofrontal cortex (OFC) region was found across the SZ, MDD, and BD. Specific reduced GMV of brain regions was also found. For patients with SZ, we found reduced GMV in the frontal lobe, temporal pole, occipital lobe, thalamus, hippocampus, and cerebellum. For patients with MDD, we found reduced GMV in the frontal and temporal lobes, insular cortex, and occipital regions. Patients with BD had reduced GMV in the medial OFC, inferior temporal and fusiform regions, insular cortex, hippocampus, and cerebellum. Furthermore, the OFC GMV was correlated with processing speed as assessed with the DSST across four groups (r = 0.17, p = 0.004) and correlated with the PANSS positive symptoms sub-score in patients with SZ (r = - 0.27, p = 0.026). In conclusion, common OFC alterations in SZ, MDD, and BD provided evidence that this region dysregulation may play a critical role in the pathophysiology of these three psychiatric disorders.
WOS关键词VOXEL-BASED MORPHOMETRY ; AMYGDALA VOLUMES ; YOUNG-ADULTS ; ABNORMALITIES ; CONNECTIVITY ; ASSOCIATION ; INVENTORY ; PATTERNS ; CHILDREN ; COMMON
WOS研究方向Neurosciences & Neurology
语种英语
出版者FRONTIERS MEDIA SA
WOS记录号WOS:000815676000001
源URL[http://ir.ia.ac.cn/handle/173211/49207]  
专题自动化研究所_脑网络组研究中心
通讯作者Song, Jinggui; Lv, Luxian
作者单位1.Xinxiang Med Univ, Clin Coll 2, Dept Psychiat, Xinxiang, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
5.Int Joint Res Lab Psychiat & Neurosci Henan, Xinxiang, Peoples R China
6.Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang, Peoples R China
7.Xinxiang Med Univ, Affiliated Hosp 2, Henan Mental Hosp, Dept Psychiat, Xinxiang, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Yongfeng,Li, Xue,Cui, Yue,et al. Reduced Gray Matter Volume in Orbitofrontal Cortex Across Schizophrenia, Major Depressive Disorder, and Bipolar Disorder: A Comparative Imaging Study[J]. FRONTIERS IN NEUROSCIENCE,2022,16:8.
APA Yang, Yongfeng.,Li, Xue.,Cui, Yue.,Liu, Kang.,Qu, Haoyang.,...&Lv, Luxian.(2022).Reduced Gray Matter Volume in Orbitofrontal Cortex Across Schizophrenia, Major Depressive Disorder, and Bipolar Disorder: A Comparative Imaging Study.FRONTIERS IN NEUROSCIENCE,16,8.
MLA Yang, Yongfeng,et al."Reduced Gray Matter Volume in Orbitofrontal Cortex Across Schizophrenia, Major Depressive Disorder, and Bipolar Disorder: A Comparative Imaging Study".FRONTIERS IN NEUROSCIENCE 16(2022):8.

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来源：自动化研究所

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