We present an analysis of oscillation mode variability in the hot B subdwarf star EPIC 220422705, a new pulsator discovered from similar to 78 days of K2 photometry. The high-quality light curves provide a detection of 66 significant independent frequencies, from which we identified nine incomplete potential triplets and three quintuplets. Those g- and p-multiplets give rotation periods of similar to 36 and 29 days in the core and at the surface, respectively, potentially suggesting a slightly differential rotation. We derived a period spacing of 268.5 s and 159.4 s for the sequence of dipole and quadrupole modes, respectively. We characterized the precise patterns of amplitude and frequency modulations (AM and FM) of 22 frequencies with high enough amplitude for our science. Many of them exhibit intrinsic and periodic patterns of AM and FM, with periods on a timescale of months as derived by the best fitting and Markov Chain Monte Carlo test. The nonlinear resonant mode interactions could be a natural interpretation for such AMs and FMs after other mechanisms are ruled out. Our results are the first step to building a bridge between mode variability from K2 photometry and the nonlinear perturbation theory of stellar oscillation.