In this paper, a special high-voltage pulse synchronization system is designed for the framing camera used in the Z-pinch experiment.The system adopts a system architecture that combines a programmable delay module and a high-voltage pulse generation module. The delay module uses a digital delay chip to achieve picosecond delay. The high-voltage pulse generation module uses a Marx pulse circuit combined in series and parallel to generate high-voltage narrow pulse.Technical parameters: pulse amplitude 2.5kv, pulse width 4.03ns, delay range 2s, delay accuracy 500Ps, pulse jitter less than 150ps. It avoids the line loss and waveform distortion caused by the long transmission line of the traditional delay line method, improves the system integration, reduces the volume and weight of the equipment, and is more convenient to deploy and use. © 2022 SPIE