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  4. 中科院海岸带环境过程与生态修复重点实验室
Intervention of antimicrobial peptide usage on antimicrobial resistance in aquaculture

文献类型：期刊论文

作者Lu, Jian1,2,4; Zhang, Yuxuan1,2; Wu, Jun3; Wang, Jianhua1,2
刊名JOURNAL OF HAZARDOUS MATERIALS
出版日期2022-04-05
卷号427页码:9
ISSN号0304-3894
关键词Antimicrobial peptide Antibiotics Antibiotic resistance genes Aquaculture
DOI10.1016/j.jhazmat.2021.128154
通讯作者Wu, Jun(wujunlisa@163.com)
英文摘要Antibiotic resistance genes (ARGs) widely exist in diverse matrices to pose potential risks and attract global attention. This study performed tilapia-cultivation experiment to discuss the intervention of antimicrobial peptide usage on antimicrobial resistance in aquaculture by analyzing 29 target ARGs in water, residue, and fish muscle samples. The sul1 gene was the dominant ARG in most of samples while absolute abundances of total ARGs were in the range of 1.5 x 102-2.3 x 107 copies/mL in water samples and 2.1 x 108-3.9 x 109 copies/g in the residue and fish muscle samples. Compared with antibiotic treatment, the cecropin treatment could significantly reduce the absolute abundance of ARGs and intI1 in all samples. Proteobacteria were the dominant phylum for most of samples while Aeromonas/Cetobacterium served as the dominant genus for samples with antibiotic/cecropin treatment. Network analysis showed that cecropin treatment could significantly reduce occurrence of multi-drug resistant bacteria and the correlation between genera and ARGs. Results of partial least squares structural equation modeling which was used to discuss the influential factors of ARGs exhibited that antibiotics could increase ARGs, further proving that cecropin peptide could effectively reduce ARGs in aquaculture. This study will provide important information on controlling ARGs in aquaculture in terms of antimicrobial peptide application.
WOS关键词ANTIBIOTIC-RESISTANCE ; GENES
WOS研究方向Engineering ; Environmental Sciences & Ecology
语种英语
WOS记录号WOS:000752478900003
资助机构National Natural Foundation of China ; Taishan Scholars Program of dong Province ; Science and Technology Network Initiative of the Chinese Academy of Sciences ; Two-Hundred Talents Plan of Yantai
源URL[http://ir.yic.ac.cn/handle/133337/31474]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
烟台海岸带研究所_近岸生态与环境实验室
通讯作者Wu, Jun
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
2.YICCAS, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China
3.Harbin Engn Univ, Yantai Res Inst, Yantai 264006, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714		 Lu, Jian,Zhang, Yuxuan,Wu, Jun,et al. Intervention of antimicrobial peptide usage on antimicrobial resistance in aquaculture[J]. JOURNAL OF HAZARDOUS MATERIALS,2022,427:9.
APA Lu, Jian,Zhang, Yuxuan,Wu, Jun,&Wang, Jianhua.(2022).Intervention of antimicrobial peptide usage on antimicrobial resistance in aquaculture.JOURNAL OF HAZARDOUS MATERIALS,427,9.
MLA Lu, Jian,et al."Intervention of antimicrobial peptide usage on antimicrobial resistance in aquaculture".JOURNAL OF HAZARDOUS MATERIALS 427(2022):9.

入库方式： OAI收割

来源：烟台海岸带研究所

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