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Exposure to microplastics reduces the bioaccumulation of sulfamethoxazole but enhances its effects on gut microbiota and the antibiotic resistome of mice

文献类型：期刊论文

作者Liu, Jin1,2; Lv, Min2; Sun, Anqi3; Ding, Jing1; Wang, Yunqing2; Chang, Xianbo1; Chen, Lingxin2
刊名CHEMOSPHERE
出版日期2022-05-01
卷号294页码:7
关键词Microplastics Antibiotic Bioaccumulation Antibiotic resistance genes Synergistic effect
ISSN号0045-6535
DOI10.1016/j.chemosphere.2022.133810
通讯作者Lv, Min(mlv@yic.ac.cn) ; Chang, Xianbo(cxb780806@126.com) ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要Microplastics (MPs) have aroused a global health concern and their coexistence with antibiotics is inevitable. However, how MPs would affect the bioaccumulation and risks of antibiotics in humans remains poorly understood. Here a mouse model was used, and through dietary exposure, we observed that while the relative distributions of sulfamethoxazole (SMX) in tissues were relatively stable, MPs significantly reduced the bioaccumulation of SMX in mice tissues (liver, lung, spleen, heart and kidney). Notably, while SMX and MPs showed a differential effect, MPs could exacerbate the effects of SMX on gut microbiota and antibiotic resistance gene (ARG) profile, with the relative abundances of sulfonamide resistance genes and multidrug genes being significantly increased. We further identified that shifts in gut microbiota contributed to the changes in ARG profiles in mice. Combined, our results demonstrate that MPs reduced the bioaccumulation of SMX, but they enhanced its effects on gut microbiota and the antibiotic resistome of mice, indicating they might have high risks to humans.
WOS关键词MYTILUS-EDULIS L. ; RESISTANCE GENES ; POLYETHYLENE ; NANOPLASTICS ; PHARMACEUTICALS ; TOXICITY ; BACTERIA ; SORPTION ; SEA
WOS研究方向Environmental Sciences & Ecology
语种英语
WOS记录号WOS:000758333200006
资助机构Youth Innovation Promotion Association CAS ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; Plan Project of Shandong Science and Technology Development ; Taishan Scholar Project Special Funding
源URL[http://ir.yic.ac.cn/handle/133337/31513]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_山东省海岸带环境工程技术研究中心
通讯作者Lv, Min; Chang, Xianbo; Chen, Lingxin
作者单位1.Yantai Univ, Sch Environm & Mat Engn, 30 Qingquan Rd, Yantai 264005, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, 17 Chunhui Rd, Yantai 264003, Peoples R China
3.Fujian Normal Univ, Sch Geog Sci, Key Lab Humid Subtrop Ecogeog Proc, Minist Educ, 8 Shangsan Rd, Fuzhou 350007, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Jin,Lv, Min,Sun, Anqi,et al. Exposure to microplastics reduces the bioaccumulation of sulfamethoxazole but enhances its effects on gut microbiota and the antibiotic resistome of mice[J]. CHEMOSPHERE,2022,294:7.
APA Liu, Jin.,Lv, Min.,Sun, Anqi.,Ding, Jing.,Wang, Yunqing.,...&Chen, Lingxin.(2022).Exposure to microplastics reduces the bioaccumulation of sulfamethoxazole but enhances its effects on gut microbiota and the antibiotic resistome of mice.CHEMOSPHERE,294,7.
MLA Liu, Jin,et al."Exposure to microplastics reduces the bioaccumulation of sulfamethoxazole but enhances its effects on gut microbiota and the antibiotic resistome of mice".CHEMOSPHERE 294(2022):7.

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来源：烟台海岸带研究所

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